Vasorelaxant effects of dobutamine and levosimendan on rat aorta rings

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dc.authoridDonmez, Soner/0000-0003-0328-6481
dc.contributor.authorDogan, Emre
dc.contributor.authorPeker, Recep Oktay
dc.contributor.authorYener, Ali Umit
dc.contributor.authorDonmez, Soner
dc.contributor.authorGokalp, Osman
dc.date.accessioned2025-01-27T20:39:14Z
dc.date.available2025-01-27T20:39:14Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: In this experimental study, the vasorelaxant effects of levosimendan and dobutamine on isolated rat thoracic aorta preparations were compared. Methods: Sixteen Wistar albino type male rats were used. The thoracic aortas were removed carefully and were transferred to petri dishes containing Krebs solution. Aortic rings of approximately 5 mm in length were prepared and placed in the organ bath. Contraction and relaxation forces of the aortic rings were recorded. Contraction response was obtained by applying 10(-5)M phenylephrine to aortic rings. Subsequently, cumulative doses of levosimendan (10(-8)M-10(-4)M) was applied to eight aortic rings and cumulative doses of dobutamine (10(-8)M-10(-3)M) was applied to the other eight aortic rings and dose-response curves were recorded. The EC50 and pD2 values were calculated by the computer program named Graph Pad Prisim 4.0. The Mann-Whitney U-test was performed for statistical analysis. Results: The relaxation response of the aortic rings with levosimendan 10(-4)M administration was %92.33 while the relaxation response with dobutamine 10-4M administration was %82.48. It did not show a significant difference between both relaxation responses (p=0.059). The EC50 value was calculated as 6.605x10(-6)M for dobutamine and 5.093x10(-5)M for levosimendan. The pD2 value was found to be 5.2 +/- 0.4 for levosimendan and 4.3 +/- 0.2 for dobutamine. Conclusion: Levosimendan and dobutamine molecules in vitro rat aortic rings have similar vasorelaxant effects.
dc.identifier.doi10.5606/tgkdc.dergisi.2015.10321
dc.identifier.endpage335
dc.identifier.issn1301-5680
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84932179021
dc.identifier.scopusqualityQ3
dc.identifier.startpage330
dc.identifier.trdizinid170397
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2015.10321
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/170397
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23899
dc.identifier.volume23
dc.identifier.wosWOS:000352520800019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDobutamine
dc.subjectlevosimendan
dc.subjectorgan bath
dc.subjectrat aorta
dc.subjectvasospasm
dc.titleVasorelaxant effects of dobutamine and levosimendan on rat aorta rings
dc.typeArticle

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