The Impact of Argan Oil and Polyhexanide on Healing Wounds with Tissue Loss Infected by Staphylococcus aureus in Mice

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dc.authoridAldık, Ruhay / 0000-0001-5791-7491
dc.contributor.authorDağlıoğlu, Yusuf Kenan
dc.contributor.authorYakan, Selvinaz
dc.contributor.authorErdoğan, Kıvılcım Eren
dc.contributor.authorKöksal, Fatih
dc.contributor.authorEkinci Akdemir, Fazile Nur
dc.contributor.authorGülçin, İlhami
dc.contributor.authorGül, Mustafa
dc.contributor.authorAldık, Ruhay
dc.date.accessioned2025-05-29T02:57:29Z
dc.date.available2025-05-29T02:57:29Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: One of the most important complications of the wound is tissue infection. One of the most common causes of tissue infections is microorganisms such as Staphylococcus. This research investigates the impact of argan oil and polyhexanide on the healing process in wounds with tissue loss infected with Staphylococcus aureus (S. aureus). Methods: The study involved 45 male mice, with 10 mm skin incisions made on their backs under general anaesthesia to create wounds. After 24 hours, an S. aureus (ATCC) suspension was applied to the scars. Wound cultures were collected from each mouse 48 hours later and this was repeated every 48 hours until cultures confirmed S. aureus infection. Treatment commenced once S. aureus growth was detected. The mice were randomly assigned to three groups: A control group (wound created, but no treatment applied), an argan group (1 mL of argan oil administered to the wound via syringe) and a polyhexanide group (1 mL of polyhexanide administered similarly). The wound diameters and clinical symptoms were monitored daily. On the 7th and 14th days, tissue samples were taken from the sacrificed mice for histopathological examination. Result: Based on clinical and histopathological observations, both argan oil and polyhexanide were found to be effective in treating S. aureus-infected wounds with tissue loss in mice. However, argan oil demonstrated a superior therapeutic potential compared to polyhexanide.
dc.identifier.doi10.18805/IJAR.BF-1874
dc.identifier.endpage225
dc.identifier.issn0367-6722
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85218491735
dc.identifier.scopusqualityQ3
dc.identifier.startpage216
dc.identifier.urihttps://doi.org/10.18805/IJAR.BF-1874
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30080
dc.identifier.volume59
dc.identifier.wosWOS:001454903900007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAgricultural Research Communication Centre
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectArgan
dc.subjectMice
dc.subjectPolyhexanide
dc.subjectStaphylococcus aureus
dc.titleThe Impact of Argan Oil and Polyhexanide on Healing Wounds with Tissue Loss Infected by Staphylococcus aureus in Mice
dc.typeArticle

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