Synthesis, characterization, carbonic anhydrase inhibitor activity, and docking studies of phenylthiazol-2 (3h)-ylidene-isoquinoline-5-amine Derivatives

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dc.authoridGencer, Nahit/0000-0001-7092-8857
dc.authoridSAHUTOGLU, Arif Sercan/0000-0003-1183-3553
dc.authoridBerber, Nurcan/0000-0002-1595-585X
dc.contributor.authorBerber, Nurcan
dc.contributor.authorSahutoglu, Arif Sercan
dc.contributor.authorGokce, Basak
dc.contributor.authorCikrikci, Kuebra
dc.contributor.authorGencer, Nahit
dc.date.accessioned2025-01-27T20:54:07Z
dc.date.available2025-01-27T20:54:07Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPhenylthiazol-2(3h)-ylidene-isoquinoline-5-amine derivatives(5a-r) were easily prepared from 5-aminoisoquinoline, thioisocyanate, and phenacyl bromide derivatives in the presence of triethylamine in tetrahydrofuran (THF), and dimethyl formamide (DMF) in two steps. In the first step, thiourea was synthesized in THF reflux, 24 h and then in the second step, the formation of thiazole ring was ensured in EtOH-DMF (5:5 v/v), reflux, 24 h. The newly synthesized compounds were characterized using 1H NMR, 13C NMR, IR, and elemental analysis. The inhibitory effects of 18 newly synthesized compounds (5a-r) on hydratase and esterase activities of carbonic anhydrase isoenzymes (hCA I, II, IX, and X) were studied in vitro.
dc.description.sponsorshipResearch Fund of the anakkale Onsekiz Mart University [FBA-2020-3128]
dc.description.sponsorshipThis work was supported by the Research Fund of the Canakkale Onsekiz Mart University. Project Number: FBA-2020-3128.
dc.identifier.doi10.1016/j.molstruc.2023.136061
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85163542622
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.136061
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25982
dc.identifier.volume1291
dc.identifier.wosWOS:001036378700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectIsoquinoline
dc.subjectThiazole
dc.subjectThiourea
dc.subjectCarbonic anhydrase
dc.subjectEnzyme inhibitor
dc.titleSynthesis, characterization, carbonic anhydrase inhibitor activity, and docking studies of phenylthiazol-2 (3h)-ylidene-isoquinoline-5-amine Derivatives
dc.typeArticle

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