Recent advances in copolymeric systems for Curcumin delivery: enhancing solubility and bioavailability

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dc.authorid0000-0003-4056-1673
dc.contributor.authorNejabat, Mojgan
dc.contributor.authorHadizadeh, Farzin
dc.contributor.authorKarav, Sercan
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2026-02-03T12:03:06Z
dc.date.available2026-02-03T12:03:06Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCurcumin (CUR) has been introduced as a powerful anti-inflammatory and antioxidant compound found extractable from turmeric with advantageous effects for brain health, heart health, immunity, and digestion. Ample evidence has demonstrated CUR's effects on preventing cancer, controlling diabetes, and improving skin health. The recent studies on CUR) as a bioactive polyphenol with therapeutic usages demonstrated major challenges such as poor solubility, rapid metabolism, and limited bioavailability. Hence, many scholars have concerned these disadvantages and suggested promising carriers to enhance the pharmacokinetic properties of CUR. However, researches on understanding long-term safety, large-scale production, and clinical translation are limited. The present review paper explored recent advancements in copolymeric based CUR delivery systems with a special concentrate on its potentials and the further research possibilities. In vivo and in situ studies on CUR-leaded copolymer as well as the evaluation of full-scale applications are the most important issues that has been addressed less. [GRAPHICS]
dc.identifier.doi10.1007/s00289-025-06239-8
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue3
dc.identifier.scopus2-s2.0-105025352552
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00289-025-06239-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34974
dc.identifier.volume83
dc.identifier.wosWOS:001643595200002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectCurcumin
dc.subjectCopolymer
dc.subjectDrug delivery systems
dc.subjectBioavailability
dc.subjectSolubility
dc.titleRecent advances in copolymeric systems for Curcumin delivery: enhancing solubility and bioavailability
dc.typeReview

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