Recent advances in copolymeric systems for Curcumin delivery: enhancing solubility and bioavailability

Curcumin (CUR) has been introduced as a powerful anti-inflammatory and antioxidant compound found extractable from turmeric with advantageous effects for brain health, heart health, immunity, and digestion. Ample evidence has demonstrated CUR's effects on preventing cancer, controlling diabetes, and improving skin health. The recent studies on CUR) as a bioactive polyphenol with therapeutic usages demonstrated major challenges such as poor solubility, rapid metabolism, and limited bioavailability. Hence, many scholars have concerned these disadvantages and suggested promising carriers to enhance the pharmacokinetic properties of CUR. However, researches on understanding long-term safety, large-scale production, and clinical translation are limited. The present review paper explored recent advancements in copolymeric based CUR delivery systems with a special concentrate on its potentials and the further research possibilities. In vivo and in situ studies on CUR-leaded copolymer as well as the evaluation of full-scale applications are the most important issues that has been addressed less. [GRAPHICS]