Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease

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dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridBalak, Naci/0000-0002-2395-0004
dc.authoridBOZKURT, SUHEYLA UYAR/0000-0002-5947-947X
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.authoridElmaci, Ilhan/0000-0001-9433-0307
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorGuven, Mustafa
dc.contributor.authorBalak, Naci
dc.contributor.authorAyan, Erdogan
dc.contributor.authorUyar, Suheyla Bozkurt
dc.contributor.authorElmaci, Ilhan
dc.date.accessioned2025-01-27T20:24:32Z
dc.date.available2025-01-27T20:24:32Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAIM: The intervertebral disc starts to degenerate when a human being begins to stand and learn to walk. It is known that many extrinsic, intrinsic and genetic factors play a role in disc degeneration. In this study, we examined whether the matrix metalloproteinase 11 might be associated with intervertebral disc degeneration. MATERIAL and METHODS: Fifty-six patients with lumbar disc herniations who were operated at Gortepe Education and Research Hospital, Neurosurgery Clinic between September 2008 and December 2009 were prospectively reviewed. History and complaints were obtained from the case reports. Neuroradiological evaluation was performed with magnetic resonance imaging. Surgical findings of cases were reported in the operation notes. Microscopic posterior hemipartial laminectomy and discectomy were performed in all cases. Degenerated herniated disc material of all cases extracted during surgery was evaluated with immunohistochemical staining in Marmara University, Institute of Neurological Sciences, Pathology Laboratory. RESULTS: Comparing the immunohistochemical staining of cases who were 50 years or younger and cases who were over 50 years old, statistical significance was determined. CONCLUSION: Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease, but it is not the only factor. Matrix metalloproteinase 11 might be a genetic factor in young-middle aged patients.
dc.identifier.doi10.5137/1019-5149.JTN.12762-14.0
dc.identifier.endpage279
dc.identifier.issn1019-5149
dc.identifier.issue2
dc.identifier.pmid26956825
dc.identifier.scopus2-s2.0-84964661494
dc.identifier.scopusqualityQ3
dc.identifier.startpage274
dc.identifier.trdizinid210313
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.12762-14.0
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/210313
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22267
dc.identifier.volume26
dc.identifier.wosWOS:000372668700017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectIntervertebral disc degeneration
dc.subjectIntervertebral disc displacement
dc.subjectMatrix metalloproteinase 11
dc.subjectMiddle age
dc.titleEvaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease
dc.typeArticle

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