The effects of leptin hormone on locomotor activity in Syrian hamsters (Mesocricetus auratus)

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dc.authoridGunduz, Bulent/0000-0003-0497-8287
dc.contributor.authorGunduz, Bulent
dc.contributor.authorKarakas, Alper
dc.date.accessioned2025-01-27T21:01:28Z
dc.date.available2025-01-27T21:01:28Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe suprachiasmatic nucleus (SCN) generates and controls the circadian rhythms in mammals including the rhythm of locomotor activity. Leptin is a hormone secreted by adipose tissue that informs the brain about the fat stores. SCN neurons express leptin receptors. Here we investigated the effects of 3 different leptin administrations on the locomotor activity of the Syrian hamsters maintained in constant darkness. Animals were intraperitoneally (ip) injected (4 mu g/kg), subcutaneously (sc) infused (4 mu g/kg), or intra-SCN infused (0.4 mu g/kg) with leptin for 3 days at circadian time 10 whereas the controls received saline (0.9% NaCl) at the same time in order to eliminate stress factors. Our results demonstrate that the locomotor activity of the hamsters can be phase advanced by the external leptin administrations. Leptin affected the level of phase-shifts in an administration method-dependent manner. The biggest phase advance was observed in intra-SCN infusion (P = 0.001), and the smallest was in the ip injection (P = 0.041) group. The wheel-turn amounts did not change significantly in the groups before and after the leptin administrations (P = 0.233); however, the period lengths increased (P = 0.011) significantly after leptin administrations. These results suggest for the first time that in vivo leptin administrations may change the rhythm of locomotor activity in adult male Syrian hamsters.
dc.description.sponsorshipTUBITAK [SBAG-2740]
dc.description.sponsorshipFinancial support for this study was provided by TUBITAK (SBAG-2740).
dc.identifier.doi10.3906/biy-1008-63
dc.identifier.endpage734
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue6
dc.identifier.scopus2-s2.0-80855164679
dc.identifier.scopusqualityQ1
dc.identifier.startpage727
dc.identifier.trdizinid122042
dc.identifier.urihttps://doi.org/10.3906/biy-1008-63
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/122042
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27053
dc.identifier.volume35
dc.identifier.wosWOS:000298197800010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSCN
dc.subjectlocomotor activity
dc.subjectleptin
dc.subjectSyrian hamster
dc.subjectMesocricetus auratus
dc.titleThe effects of leptin hormone on locomotor activity in Syrian hamsters (Mesocricetus auratus)
dc.title.alternativeLeptin hormonunun Suriye hamsterlerinde (Mesocricetus auratus) lokomotor aktivite üzerine etkileri
dc.typeArticle

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