Graphene quantum dots-polyfluorene hybrid nanobiosensor for mitomycin C-DNA interaction sensing

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dc.authorid0000-0003-0493-8154en_US
dc.authorid0000-0003-3067-3954en_US
dc.authorid0000-0002-1377-5580en_US
dc.authorid0000-0003-4607-3523en_US
dc.authorscopusid16021622500en_US
dc.authorscopusid57330659200en_US
dc.authorscopusid13405405500en_US
dc.authorscopusid55964006300en_US
dc.authorwosidAAD-1940-2021en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorEmre, Deniz
dc.contributor.authorDenizhan, Nuray
dc.contributor.authorÖzkan-Arıksoysal, Dilsat
dc.contributor.authorBilici, Ali
dc.contributor.authorSonkaya, Ömer
dc.contributor.authorAlgı, Fatih
dc.contributor.authorYılmaz, Selehattin
dc.date.accessioned2024-02-21T06:56:41Z
dc.date.available2024-02-21T06:56:41Z
dc.date.issued2024en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Bölümü
dc.description.abstractA novel graphene quantum dots (GQD) / polyfluorene (PF) nanocomposite was deposited on the disposable pencil tip graphite electrode (PGE) and proven to be an efficient nanosensor for analysis of the electrochemical interaction between the antitumor compound mitomycin C (MC) with double stranded DNA (ds-DNA). This modified electrode (GQD@PF-PGE) was prepared in four steps: hydrothermal, chemical oxidation, ultrasonication and electro-oxidation processes. GQD, PF, GQD@PF and GQD@PF-PGE have been characterized by different analytical techniques such as SEM, TEM, XRD, FTIR, UV–Vis, EIS. Compared to bare PGE, GQD@PF modified PGE performed approximately 56 times more sensitive analysis when evaluating the guanine oxidation signals measured by DPV. CV and EIS measurements also showed that GQD@PF-PGE possesses a fast electron transfer as compared to bare electrode and exhibit a remarkable electrocatalytic activity towards both guanine and MC electrooxidation. Comprehensive optimization studies have also been carried out for the developed new nanobiosensor.en_US
dc.identifier.citationEmre, D., Denizhan, N., Özkan-Arıksoysal, D., Bilici, A., Sonkaya, Ö., Algi, F., Yılmaz, S. (2024) Graphene quantum dots-polyfluorene hybrid nanobiosensor for mitomycin C-DNA interaction sensing. Materials Science and Engineering: B, 299. doi: 10.1016/j.mseb.2023.116944en_US
dc.identifier.doi10.1016/j.mseb.2023.116944
dc.identifier.issn0921-5107
dc.identifier.issn1873-4944
dc.identifier.scopus2-s2.0-85174031796
dc.identifier.urihttps://doi.org/10.1016/j.mseb.2023.116944
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5724
dc.identifier.volume299en_US
dc.identifier.wosWOS:001097132500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEmre, Deniz
dc.institutionauthorDenizhan, Nuray
dc.institutionauthorBilici, Ali
dc.institutionauthorYılmaz, Selehattin
dc.language.isoen
dc.publisherElsevier Ltden_US
dc.relation.ispartofMaterials Science and Engineering: Ben_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectrochemical DNA biosensoren_US
dc.subjectElectropolymerizationen_US
dc.subjectGraphene quantum dotsen_US
dc.subjectMitomycin Cen_US
dc.subjectPencil graphite electrodeen_US
dc.subjectPolyfluoreneen_US
dc.titleGraphene quantum dots-polyfluorene hybrid nanobiosensor for mitomycin C-DNA interaction sensing
dc.typeArticle

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