Synthesis and characterization of poly(Maltodextrin) microgel from maltodextrin as drug delivery system

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dc.authorid0000-0001-8666-7954en_US
dc.authorid0000-0002-5802-1635en_US
dc.authorid0000-0002-8352-6571en_US
dc.authorid-en_US
dc.authorid-en_US
dc.authorid0000-0003-0120-530Xen_US
dc.authorscopusid24472372400en_US
dc.authorscopusid35329396700en_US
dc.authorscopusid15760777900en_US
dc.authorscopusid56026625600en_US
dc.authorscopusid58796676000en_US
dc.authorscopusid6602001525en_US
dc.authorwosidAAB-6714-2020en_US
dc.authorwosid-en_US
dc.authorwosidC-3984-2016en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosidDVD-0927-2022en_US
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorGüngör, Buket
dc.contributor.authorSılan, Coşkun
dc.contributor.authorDemirci, Şahin
dc.contributor.authorErdoğan, Hakika
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2024-02-21T07:13:42Z
dc.date.available2024-02-21T07:13:42Z
dc.date.issued2024en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractMicrogels of maltodextrin (MDex) as poly(maltodextrin) (p(MDex)) were prepared by reverse-micelle crosslinking technique at various crosslinking ratios, 25, 50, and 100% based on the repeating unit of MDex using divinylsulfone (DVS) as crosslinker and were designated as p(MDex)-1, p(MDex)-2, and p(MDex)-3 respectively. The prepared p(MDex) microgels were blood compatible with <2% hemolysis and > 80%blood clotting index values at 1.0 mg/mL concentration. Also, p(MDex) microgels were found as biocompatible with >90% cell viability against L929 fibroblast cells at 1.0 mg/mL concentrations. Furthermore, p(MDex)-3 microgels were modified with ethylenediamine (EDA) and pentaethylenehexamine (PEHA) to generate new amine groups on microgels surface to obtain p(MDex)-EDA and p(MDex)-PEHA, respectively to render new surface functionality and features. The drug delivery potentials of p(MDex)-3, p(MDex)-EDA, and p(MDex)-PEHA microgels were tested employing amoxicillin (Amox) for loading and release studies at pH 7.4 and 37 degrees C. Higher drug loading amount, loading content%, and encapsulation efficiency% values were attained for p(MDex)-PEHA microgels with 112.5 +/- 9.9 mg/g, 12.8 +/- 1.1%, and 63.4 +/- 4.1%, respectively. The Amox-loaded p(MDex)-3, p(MDex)-EDA, and p(MDex)-PEHA microgels released 90.8 +/- 0.9, 86.2 +/- 10.8, and 87.2 +/- 9.6% of the loaded Amox at pH 7.4 PBS in 125 h. Controlled and extended drug delivery system at the therapeutic window is of paramount significance in treatment of various diseases. P(MDex)-PEHA microgels revealed almost a linear Amox release profile for up to 28 h. The Amox release from the p(MDex) microgels was fitted with the Korsmeyer-Peppas model with n values <0.5.en_US
dc.identifier.citationŞahiner, M., Güngör, B., Sılan, C., Demirci, Ş., Erdoğan, H., Ayyala, R., & Şahiner, N. (2024) Synthesis and characterization of poly(Maltodextrin) microgel from maltodextrin as drug delivery system. Reactive and Functional Polymers, 195. doi: 10.1016/j.reactfunctpolym.2024.105826en_US
dc.identifier.doi10.1016/j.reactfunctpolym.2024.105826
dc.identifier.issn1381-5148
dc.identifier.scopus2-s2.0-85181585160
dc.identifier.urihttps://doi.org/10.1016/j.reactfunctpolym.2024.105826
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5728
dc.identifier.volume195en_US
dc.identifier.wosWOS:001155686300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorGüngör, Buket
dc.institutionauthorSılan, Coşkun
dc.institutionauthorDemirci, Şahin
dc.institutionauthorErdoğan, Hakika
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherElsevier B.V.en_US
dc.relation.ispartofReactive and Functional Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectControlled amoxicillin releaseen_US
dc.subjectDrug delivery systemen_US
dc.subjectMaltodextrinen_US
dc.subjectPoly(maltodextrin) particleen_US
dc.subjectPolysaccharide microgelen_US
dc.titleSynthesis and characterization of poly(Maltodextrin) microgel from maltodextrin as drug delivery system
dc.typeArticle

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