Histopathological changes in myocardial tissue due to coronary venous hypertension

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dc.authoridAkşit, Ercan / 0000-0002-4478-4324
dc.authoridOğuz, Sonay / 0000-0002-4274-3828
dc.contributor.authorAkşit, Ercan
dc.contributor.authorBüyük, Başak
dc.contributor.authorOğuz, Sonay
dc.date.accessioned2025-01-27T20:41:01Z
dc.date.available2025-01-27T20:41:01Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: In chronic venous insufficiency (CVI), an increase in venous pressure causes the passage of intravascular blood cells and molecules into the surrounding tissues and induces histopathological changes in the lower extremities, leading to increased pigmentation in the legs, ulceration, and tissue loss to various degrees. This study aimed to investigate whether an increase in venous pressure in the coronary veins can lead to the aforementioned histopathological changes. Material and methods: Twenty-four New Zealand rabbits were divided into the following three groups: experimental model of coronary venous hypertension (CVH) (n = 8), sham group (n = 8), and control group (n = 8). After 21 days postoperatively, tissue samples from each group were compared for perivascular inflammation, erythrocyte extravasation, macrophage infiltration, and hemosiderin deposits by histopathological scoring under a light microscope. Matrix metalloproteinase-2 (MMP-2) activation was evaluated using immunohistochemical staining. Results: In the CVH group, hemosiderin accumulation was significantly higher than in the sham and control groups (1.0 (1.0–3.0), 0.0 (0.0–1.0), 0.0 (0.0–0.0); p < 0.001). Immunohistochemically, in the CVH group, MMP-2 levels were significantly higher than in the sham and control groups (2.0 (1.0–3.0), 0.0 (0.0–1.0), 0.0 (0.0–0.0); p < 0.001). Conclusions: This experimental study showed for the first time the histopathological and immunohistochemical changes in myocardial tissue, similar to those observed in CVI, as a result of increased coronary venous pressure due to coronary vein ligation. Further studies are needed to understand the clinical implications of these results.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University [2751, THD-2018-2751]
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University as an Independent Research Project (Project ID: 2751, Code: THD-2018-2751) . I would like to thank veterinarian doctor Sait Elmas and the entire staff of Canakkale Onsekiz Mart University experimental research application and research center, for their support during coronary vein ligation; Prof. Dr. Coskun Ba- kar and Dr. Buse Yuksel for their support in statistical analyses; and Prof. Dr. Armagan Altun for his input and support while finalizing this article.
dc.identifier.doi10.5114/aoms.2019.91472
dc.identifier.endpage1720
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue6
dc.identifier.pmid38058730
dc.identifier.scopus2-s2.0-85176750985
dc.identifier.scopusqualityQ1
dc.identifier.startpage1714
dc.identifier.urihttps://doi.org/10.5114/aoms.2019.91472
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23972
dc.identifier.volume19
dc.identifier.wosWOS:001108790700039
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectcoronary veins
dc.subjecthemosiderin
dc.subjectThebesian valve
dc.subjectvein occlusion
dc.subjectvenous insufficiency
dc.titleHistopathological changes in myocardial tissue due to coronary venous hypertension
dc.typeArticle

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