Occupational exposure to radiation among health workers: Genome integrity and predictors of exposure

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dc.authorid0000-0001-9640-3354en_US
dc.authorid0000-0002-2014-6635en_US
dc.authorscopusid57195554629en_US
dc.authorscopusid22733342800en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorÇobanoğlu, Hayal
dc.contributor.authorÇayır, Akın
dc.date.accessioned2024-02-20T07:35:04Z
dc.date.available2024-02-20T07:35:04Z
dc.date.issued2024en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractThe current study aimed to investigate genomic instabilities in healthcare workers who may experience varying levels of radiation exposure through various radiological procedures. It also sought to determine if factors related to the work environment and dosimeter reading could effectively explain the observed genomic instabilities. Utilizing the cytokinesis-block micronucleus assay (CBMN) on peripheral blood lymphocytes, we assessed a spectrum of genomic aberrations, including nucleoplasmic bridge (NPB), nuclear budding (NBUD), micronucleus (MN) formation, and total DNA damage (TDD). The study uncovered a statistically significant increase in the occurrence of distinct DNA anomalies among radiology workers (with a significance level of P < 0.0001 for all measurements). Notably, parameters such as total working hours, average work duration, and time spent in projection radiography exhibited significant correlations with MN and TDD levels in these workers. The dosimeter readings demonstrated a positive correlation with the frequency of NPB and NBUD, indicating a substantial association between radiation exposure and these two genomic anomalies. Our multivariable models identified the time spent in projection radiography as a promising parameter for explaining the overall genomic instability observed in these professionals. Thus, while dosimeters alone may not fully explain elevated total DNA damage, intrinsic work environment factors hold potential in indicating exposure levels for these individuals, providing a complementary approach to monitoring.en_US
dc.identifier.citationÇobanoğlu, H., Çayır, A. (2024) Occupational exposure to radiation among health workers: Genome integrity and predictors of exposure. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 893. doi: 10.1016/j.mrgentox.2024.503726en_US
dc.identifier.doi10.1016/j.mrgentox.2024.503726
dc.identifier.issn1383-5718
dc.identifier.pmid38039772
dc.identifier.scopus2-s2.0-85182577630
dc.identifier.urihttps://doi.org/10.1016/j.mrgentox.2024.503726
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5658
dc.identifier.volume893en_US
dc.identifier.wosWOS:001163122500001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇobanoğlu, Hayal
dc.institutionauthorÇayır, Akın
dc.language.isoen
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMutation Research - Genetic Toxicology and Environmental Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNuclear bridgeen_US
dc.subjectNuclear buddingen_US
dc.subjectOccupational radiation exposureen_US
dc.subjectWork-related parametersen_US
dc.titleOccupational exposure to radiation among health workers: Genome integrity and predictors of exposure
dc.typeArticle

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