The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia

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dc.authoridAltinisik, Hatice Betul/0000-0001-9273-0876
dc.authoridHUNEREL, TUGBA/0000-0001-7320-5793
dc.contributor.authorHunerel, Tugba
dc.contributor.authorAltinisik, Hatice Betul
dc.date.accessioned2025-01-27T20:47:25Z
dc.date.available2025-01-27T20:47:25Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Sugammadex is a widely used anesthetic agent for reversing of the non-depolarizing block. It reduces blood levels of steroid compounds by encapsulation. The aim of this study was to investigate the effect of sugammadex on the blood levels of vitamin D levels, which has a steroid structure. Materials and Methods: A total of 15 adult male New Zealand white rabbits weighing 2-2.5 kg were randomized into three groups according to decurarization: Group S [sugammadex (16 mg/kg), n=5], group N [neostigmine (0.05 mg/kg), n=5], group C (control group, n=5). Vitamin D levels from venous blood were measured at baseline, 20 minutes and 24 hours after general anesthesia. Results: Mean +/- SD vitamin D levels before anesthesia, 20 minutes and 24 hours after anesthesia were 4.42 +/- 0.60 ng/mL, 4.93 +/- 0.72 ng/mL, and 4.66 +/- 0.94 ng/mL for group S, 4.92 +/- 0.45 ng/mL, 5.02 +/- 0.41 ng/mL, and 5.41 +/- 0.56 ng/mL for group N, and 5.15 +/- 0.82 ng/ mL, 4.57 +/- 1.10 ng/mL, and 5.21 +/- 1.05 ng/mL for group C, respectively. There were no significant differences in the mean vitamin D levels between the groups at baseline, 20 minutes, and 24 hours. Conclusion: Contrary to expectations, it was found that sugammadex did not have a statistically significant effect on blood levels of vitamin D.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit [1421]
dc.description.sponsorshipThis research was supported by Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit. Project number: 1421.
dc.identifier.doi10.4274/tod.galenos.2019.63325
dc.identifier.endpage92
dc.identifier.issn2147-2653
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85078530412
dc.identifier.scopusqualityQ4
dc.identifier.startpage88
dc.identifier.trdizinid335481
dc.identifier.urihttps://doi.org/10.4274/tod.galenos.2019.63325
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/335481
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24896
dc.identifier.volume25
dc.identifier.wosWOS:000502569000004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofTurk Osteoporoz Dergisi-Turkish Journal of Osteoporosis
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectVitamin D
dc.subjectgeneral anesthesia
dc.subjectsteroids
dc.subjectsugammadex
dc.titleThe Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia
dc.title.alternativeGenel Anestezi Altındaki Tavşanlarda Sugammadeksin D Vitamini Düzeylerine Etkileri
dc.typeArticle

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