Hydroxylated-graphitic carbon nitride@graphene oxide composites for sensitive electrochemical determination of COVID-19 drug molnupiravir: Effect of modifier composition

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dc.authoridEmre, Deniz / 0000-0003-0493-8154
dc.authoridYılmaz, Selehattin / 0000-0003-4607-3523
dc.authoridBilici, Ali / 0000-0002-1377-5580
dc.contributor.authorEmre, Deniz
dc.contributor.authorYılmaz, Selehattin
dc.contributor.authorBilici, Ali
dc.date.accessioned2025-05-29T02:57:58Z
dc.date.available2025-05-29T02:57:58Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this research, pencil graphite electrode (PGE) surfaces were modified with a two-dimensional and multifunctional composite material consisting of hydroxylated graphitic carbon nitride (hCN) and graphene oxide (GO) components for sensitive voltammetric determination of coronavirus disease (COVID-19) drug molnupiravir (MLP). The synthesis of carbon nitride, hCN, GO, and the composite material (hCN@GO) included thermal polymerization, hydroxylation, intermediate Hummer's method, and sonochemical processes, respectively. Then, the resulting composite material was electrochemically loaded on the PGE surface. The effects of various experimental parameters, such as the supporting electrolyte, pH, buffer concentration, and scan speed, on the analytical signal were investigated. The most vital one was the composite composition loaded on the PGE. The highest signal was obtained when the PGE surface was coated with the hCN:GO ratio of 30:70 (as weight%). The findings assigned electrode modification with proper composition led to an approximately 17-fold increase in the electrochemically active surface area and a 100-fold decrease in the charge transfer resistance of bare PGE. Thus, it could achieve approximately a 3-fold lower detection limit. The sensor exhibited a linear response in the 7-300 nM MLP concentration range with a detection limit of 2.2 nM without significant interference.
dc.identifier.doi10.1016/j.microc.2025.113852
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-105004317400
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.microc.2025.113852
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30216
dc.identifier.volume213
dc.identifier.wosWOS:001488872000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectCOVID-19
dc.subjectAntiviral drug
dc.subjectMolnupiravir
dc.subjectHydroxylated graphitic carbon nitride
dc.subjectGraphene oxide
dc.subjectVoltammetry
dc.titleHydroxylated-graphitic carbon nitride@graphene oxide composites for sensitive electrochemical determination of COVID-19 drug molnupiravir: Effect of modifier composition
dc.typeArticle

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