The protective effect of syringic acid on ischemia injury in rat brain

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dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorOzkan, Adile
dc.contributor.authorSen, Halil Murat
dc.contributor.authorKalkan, Yildiray
dc.contributor.authorOkuyucu, Ali
dc.date.accessioned2025-01-27T20:20:21Z
dc.date.available2025-01-27T20:20:21Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground/aim: Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previously unstudied, on oxidative damage in cerebral ischemia. Materials and methods: The rats were randomly divided into 4 groups: control group (no medication or surgical procedure), sham group (artery occlusion), artery occlusion + syringic acid group sacrificed at 6 h, and artery occlusion + syringic acid group sacrificed at 24 h. Obtained brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Results: Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after syringic acid treatment, while increased malondialdehyde levels after ischemia were reduced after treatment. Caspase-3 and caspase-9 values increased after ischemia and decreased after treatment; this reduction was more pronounced at 24 h. Conclusion: Our study revealed that syringic acid treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. In the light of the biochemical and histopathologic results of the present study, we think that syringic acid treatment may be an alternative treatment method.
dc.identifier.doi10.3906/sag-1402-71
dc.identifier.endpage240
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1
dc.identifier.pmid25790559
dc.identifier.scopus2-s2.0-84920059436
dc.identifier.scopusqualityQ1
dc.identifier.startpage233
dc.identifier.trdizinid211835
dc.identifier.urihttps://doi.org/10.3906/sag-1402-71
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/211835
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21674
dc.identifier.volume45
dc.identifier.wosWOS:000347840000038
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBrain ischemia
dc.subjectsyringic acid
dc.subjectrats
dc.subjectoxidative stress
dc.subjectapoptosis
dc.titleThe protective effect of syringic acid on ischemia injury in rat brain
dc.typeArticle

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