Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism

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dc.authorid0000-0002-0667-6090en_US
dc.authorid0000-0003-4303-9717en_US
dc.authorid0000-0002-2766-5999en_US
dc.authorscopusid8547022700en_US
dc.authorscopusid56403166600en_US
dc.authorscopusid10243629400en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosidB-1402-2012en_US
dc.contributor.authorBeyazıt, Fatma
dc.contributor.authorHız, Merve Meliha
dc.contributor.authorÜnsal, Mesut Abdulkerim
dc.contributor.authorTürkön, Hakan
dc.date.accessioned2023-06-12T12:20:42Z
dc.date.available2023-06-12T12:20:42Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjectives: Polycystic Ovary Syndrome (Pcos) Is A Complex Reproductive Endocrinopathy Among Reproductive-Aged Women And Related With Body Mass And Insulin Resistance. Adipocytokines Produced By Adipose Tissue Seems To Take Part In The Hormonal And Metabolic Alterations That Arise In Pcos. Fat Mass And Obesity Associated (Fto) Gene Is Linked With Body Mass Index (Bmi) And Diabetes. Aims — To Investigate The Association Between Fat Mass Related Adipocytokines And Single Nucleotide Polymorphisms (Snps) (Rs9939609 T/A) In The Fto Gene In Women With Pcos. Study Design — Cross-Sectional Study Material And Methods: Fto+Rs9939609 Gene Polymorphism And Serum Spexin, Adiponectin And Leptin Levels Were Deter-Mined In 91 Pcos Women And 86 Healthy Controls. Study Participants Were Subdivided According To Bmi And Comparisons Were Made Within Each Group. Results: Serum Spexin Levels Were Not Differed Between Study Groups. Serum Levels Of Adiponectin Were Found To Be De-Creased In Pcos Women With Bmi Lower Than 25 Kg/M2 (10.1 ± 5.6 Vs 14.1 ± 9.1, P = 0.015). Serum Leptin Levels Were Elevated In Obese Pcos Women Compared To Healthy Control Group (2197.9 ± 596.3 Pg/Ml Vs 1535.9 ± 812.1 Pg/Ml, P = 0.001). The Prevalence Of A Risk Allele Of Snp Rs9939609 Was More Frequent In Pcos Patients Than In The Control Group. Pcos Risk Was Found To Increase 3 Times More In Aa Genotype When Compared With Tt Genotype (Or = 3.04 95% Ci: 1.243–7.309; P = 0.013). Conclusions: Serum Adiponectin And Leptin Levels May Serve As Independent Markers For Pcos Diagnosis. Moreover, The Fto+Rs9939609 Gene Polymorphism Increase Susceptibility To Pcos Development Independent From Serum Adipocytokine Levelsen_US
dc.identifier.citationBeyazıt, F., Hız, M. M., Türkön, H., & Ünsal, M. A. (2021). Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with fto gene polymorphism. Ginekologia Polska, 92(10), 682-688. doi:10.5603/GP.a2020.0176en_US
dc.identifier.doi10.5603/GP.a2020.0176
dc.identifier.endpage688en_US
dc.identifier.issn0017-0011
dc.identifier.issn2543-6767
dc.identifier.issue10en_US
dc.identifier.pmid33914321
dc.identifier.scopus2-s2.0-85112719862
dc.identifier.startpage682en_US
dc.identifier.urihttps://doi.org/10.5603/GP.a2020.0176
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4294
dc.identifier.volume92en_US
dc.identifier.wosWOS:000716944100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBeyazıt, Fatma
dc.institutionauthorHız, Merve Meliha
dc.institutionauthorÜnsal, Mesut Abdulkerim
dc.language.isoen
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAdiponectinen_US
dc.subjectFto Gene Polymorphismen_US
dc.subjectLeptinen_US
dc.subjectPcosen_US
dc.subjectSpexinen_US
dc.titleSerum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism
dc.typeArticle

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