A Novel ruthenium(II) complex-based electrode for non-enzymatic glucose sensing applications

Ruthenium-based complexes demonstrate high potential in the catalysation of the electrochemical oxidation of glucose, offering high sensitivity and stability in glucose detection. In this study, a ruthenium complex (Ru1) was synthesised using 2,2 '-bipyridine-4,4 '-dicarboxylic acid (DCBpy), potassium iodide (KI) and [RuCl2(p-cymene)](2). The structural properties of Ru1 were investigated using X-ray diffraction (XRD), nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and UV-vis spectroscopy analyses, which revealed its structure. The electrochemical behaviour of the Ru1 complex was systematically investigated and found to be promising for application in a glucose biosensor. Cyclic voltammetry measurements revealed an increase in electrochemical activity on the electrode surface over time, showing a steady rise at a potential of 0.32 V. This indicates high sensitivity and reliability in glucose detection. Chronoamperometric analysis showed a linear response to glucose concentrations ranging from 0.1 to 0.8 mM, demonstrating the sensor's sensitivity. These properties make the Ru1 complex a promising candidate for use in glucose detection biosensors. In conclusion, the complex's electrocatalytic activity and stability could be key to advancing biosensor technologies by enhancing sensitivity.