The possible effect of topically applied azithromycin and moxifloxacin on the alleviation of uveitis

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dc.contributor.authorArikan, Sedat
dc.contributor.authorGuven, Soner
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorElmas, Sait
dc.date.accessioned2025-01-27T20:29:01Z
dc.date.available2025-01-27T20:29:01Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose To investigate the inhibitory effect of topically administered azithromycin (AZM), and moxifloxacin (MXF) against tumor necrosis factor-a (TNF-alpha) production in a rat model of endotoxininduced uveitis (EIU). Methods Thirty-six Wistar albino rats were divided into 6 equal groups. Groups 1, 2 and 3 were determined as sham, control group for topical AZM application and control group for topical MXF application, respectively. Sterile saline, topical AZM 1.5%, and topical MXF 0.5% were instilled 5 times daily for totally 6 days on both eyes of the rats in Group 4, Group 5, and Group 6, before and after inducing EIU by intravitreal injections of lipopolysaccharide, respectively. At 24 h after intravitreal injections, aqueous humor was collected from both eyes of each rat for the assessment of TNF-a concentration. Also, density of nuclear factor kappa B (NF-kappa B) in ciliary body, and the number of cells infiltrating the posterior segment of EIU rat eyes was assessed in one eye of each rat. Results There was a significant reduction in mean aqueous humor concentration of TNF-alpha in EIU rats pretreated with topical AZM in comparison with those pretreated with sterile saline (139 +/- 38.6 in Group 4 vs. 72 +/- 12.6 in Group 5, p = 0.006). There was also a marked decrease in mean aqueous humor concentration of TNF-a in EIU rats pretreated with topical MXF (139 +/- 38.6 in Group 4 vs.86.1 +/- 35.5 in Group 6, p = 0.025). Also, evident suppressions were determined in mean density of NF-kappa B, and in mean number of cells in EIU rats pretreated either with topical AZM, or topical MXF. Conclusions Topically applied AZM or MXF may be beneficial in the suppression of TNF-alpha production in aqueous humor.
dc.identifier.doi10.1007/s10792-023-02845-5
dc.identifier.endpage4460
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue12
dc.identifier.pmid37642800
dc.identifier.scopus2-s2.0-85168902839
dc.identifier.scopusqualityQ2
dc.identifier.startpage4451
dc.identifier.urihttps://doi.org/10.1007/s10792-023-02845-5
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22783
dc.identifier.volume43
dc.identifier.wosWOS:001063897400002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Ophthalmology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAzithromycin
dc.subjectEndotoxin-induced uveitis
dc.subjectMoxifloxacin
dc.subjectTumor necrosis factor-alpha
dc.titleThe possible effect of topically applied azithromycin and moxifloxacin on the alleviation of uveitis
dc.typeArticle

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