The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study

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dc.authoridunsal, mesut/0000-0002-2766-5999
dc.contributor.authorPek, Eren
dc.contributor.authorGoret, Ceren Canbey
dc.contributor.authorHacivelioglu, Servet
dc.contributor.authorAdam, Gurhan
dc.contributor.authorUnsal, Mesut Abdulkerim
dc.date.accessioned2025-01-27T20:31:25Z
dc.date.available2025-01-27T20:31:25Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Previous studies have shown that damage occurs to internal genital tract during hysterosalpingography (HSG). The aim was to show that endometrial and tubal epithelium underwent free radical damage during HSG in an animal model. Material and Methods: Forty rats were evaluated in five different groups. Two groups received ionizing radiation (15-20 miliRad three times) only. Two further groups received ionizing radiation in combination with iohexol (1-2 mL). The remaining group served as control. Groups were evaluated after seven and forty-two days. Inflammation and cellular changes were evaluated histopathologically. Cellular activity of antioxidant enzymes was assessed immunohistochemically. Results: Inflammation, and cellular changes were detected at certain rates in all groups (p<0.001). Glutathione reductase, catalase, superoxide dismutase, glutathione S-transferase activities were found to be increased after the HSG (p<0.001). Conclusion: It is obvious that the cell suffers acute and chronic damage during HSG due to both radioactivity and chemicals. Although there is a lot of research done before, there is no definitive method yet to protect against the harmful effects of iodinated contrast agents and ionizing radiation. So, new methods need to be explored to protect cells and tissues from reactive oxygen radical damage caused by HSG.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Center; Canakkale Onsekiz Mart University Scientific Research Projects Center
dc.description.sponsorshipThis research was carried out with the support of Canakkale Onsekiz Mart University Scientific Research Projects Coordination Center. Researchers and authors do not have any financial gain. Canakkale Onsekiz Mart University Scientific Research Projects Center, which supports the realization of the project, does not have any financial gain.
dc.identifier.doi10.4274/jtgga.galenos.2020.2019.0067
dc.identifier.endpage254
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue4
dc.identifier.pmid32500677
dc.identifier.scopus2-s2.0-85097603257
dc.identifier.scopusqualityQ3
dc.identifier.startpage243
dc.identifier.trdizinid417096
dc.identifier.urihttps://doi.org/10.4274/jtgga.galenos.2020.2019.0067
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/417096
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23141
dc.identifier.volume21
dc.identifier.wosWOS:000596570800005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofJournal of The Turkish-German Gynecological Association
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectFree oxygen radicals
dc.subjecthysterosalpingography
dc.subjectiohexol
dc.subjectionizing radiation
dc.titleThe immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study
dc.typeArticle

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