Could tear endothelin-1 levels be associated with disability in multiple sclerosis?

Basit Öğe Kaydı
dc.contributor.authorCam, Mustafa
dc.contributor.authorSehitoglu, Hilal
dc.date.accessioned2025-01-27T20:45:56Z
dc.date.available2025-01-27T20:45:56Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Endothelin-1 (ET-1) is a potent vasoconstrictor substance mainly secreted by endothelial cells. Increased ET-1 levels in plasma or cerebrospinal fluid (CSF) have been identified in multiple sclerosis (MS). We aimed to analyze tear ET-1 levels; visual evoked potential (VEP) and disability scores in patients with MS and in healthy controls. Methods: Adult patients (18-65 year-old) diagnosed with MS according to the McDonald criteria, and healthy controls were recruited for the study. Demographic features, VEP, and tear ET-1 levels were evaluated. Disability in the MS group was assessed and grouped by EDSS score (<3 vs. >= 3). The EDSS score in healthy controls was zero. Results: Both in the total number of patients overall and in the patients with EDSS score <3, tear ET-1 levels were higher in the MS group than that in the controls (p<0.001). In the MS group, the ET-1 level was higher in the patients with EDSS score >= 3 than in those with EDSS score <3 (p<0.001). The tear ET-1 level was positively correlated with age and EDSS score in the MS group (p<0.001). Conclusion: To the best of our knowledge, there is no study in the literature that measures tear ET-1 levels in MS and examines their relationship with EDSS score and VEP. Higher tear ET-1 levels seem to be associated with disability and abnormal VEP in MS. Tear ET-1 measurement may be a simple new noninvasive marker indicating the disability in the patients with MS in the future.
dc.identifier.doi10.54029/2023itk
dc.identifier.endpage701
dc.identifier.issn1823-6138
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85173253722
dc.identifier.scopusqualityQ4
dc.identifier.startpage695
dc.identifier.urihttps://doi.org/10.54029/2023itk
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24767
dc.identifier.volume28
dc.identifier.wosWOS:001085393800025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAsean Neurological Assoc
dc.relation.ispartofNeurology Asia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectEndothelin
dc.subjectmultiple sclerosis
dc.subjectEDSS
dc.subjectVEP
dc.subjectendothelin 1.
dc.titleCould tear endothelin-1 levels be associated with disability in multiple sclerosis?
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu