Dietary effect of grape (Vitis vinifera) seed extract mitigates hepatic disorders caused by oxidized fish oil in rainbow trout (Oncorhynchus mykiss)

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dc.authorid0000-0003-2515-5490en_US
dc.authorscopusid55866023400en_US
dc.authorwosid-en_US
dc.contributor.authorTerzi, Funda
dc.contributor.authorDemirci, Beste
dc.contributor.authorAcar, Ümit
dc.contributor.authorYüksel, Süleyman
dc.contributor.authorSalum, Çagatay
dc.contributor.authorErol, Hüseyin Serkan
dc.contributor.authorKesbiç, Osman Sabri
dc.date.accessioned2023-09-07T05:25:58Z
dc.date.available2023-09-07T05:25:58Z
dc.date.issued2023en_US
dc.departmentFakülteler, Deniz Bilimleri ve Teknolojisi Fakültesi, Deniz Teknoloji Mühendisliği Bölümü
dc.description.abstractThe major goal of this study was to determine the effect of grape seed extract (GSE) on liver damage in rainbow trout (Oncorhynchus mykiss) that was caused by the consumption of dietary oxidized fish oil (OFO). Rainbow trout were fed six different experimental diets coded OX-GSE 0 (OFO diet), OX-GSE 1 (OFO and 0.1% GSE), OX-GSE 3 (OFO and 0.3% GSE), GSE 0 (fresh fish oil and 0.0% GSE), GSE 1 (fresh fish oil and 0.1% GSE), and GSE 3 (fresh fish oil and 0.3% GSE) for 30 days. The lowest % hepatosomatic index (HSI) result was calculated in fish fed with OX-GSE 0 and the highest HSI was determined in fish fed with GSE 1 diets (p < 0.05). Histopathologically, hydropic degeneration in hepatocytes significantly increased OX-GSE 0 and GSE 3 compared to GSE 1 diets (p < 0.05). Deposition of lipid droplets in hepatocytes was significantly increased in OX-GSE 0 and OX-GSE 3 groups than others (p < 0.05). Liver biochemistry parameters such as superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) were significantly affected by OX and GSE treatments (p < 0.05). There were significant differences in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) among the liver enzymes analyzed in serum in OX and GSE (p < 0.05), meanwhile no difference was observed in lactate dehydrogenase (LDH) values between groups (p > 0.05). In conclusion, liver biochemistry and histopathology of rainbow trout consuming diets containing oxidized fish oil were negatively affected. However, it was determined that the supplementation of 0.1% GSE to the diet had a significant ameliorative role in these adverse effects.en_US
dc.identifier.citationTerzi, F., Demirci, B., Acar, Ü., Yüksel, S., Salum, Ç., Erol, H. S., & Kesbiç, O. S. (2023). Dietary effect of grape (Vitis vinifera) seed extract mitigates hepatic disorders caused by oxidized fish oil in rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry, 49(3), 441–454. https://doi.org/10.1007/s10695-023-01193-6en_US
dc.identifier.doi10.1007/s10695-023-01193-6
dc.identifier.endpage454en_US
dc.identifier.issn0920-1742
dc.identifier.issn1573-5168
dc.identifier.issue3en_US
dc.identifier.pmid37097349
dc.identifier.scopus2-s2.0-85153366146
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.1007/s10695-023-01193-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4520
dc.identifier.volume49en_US
dc.identifier.wosWOS:000974560300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAcar, Ümit
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.en_US
dc.relation.ispartofFish Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant capacityen_US
dc.subjectGrape seed extracten_US
dc.subjectLiver biochemistryen_US
dc.subjectOxidative stressen_US
dc.subjectOxidized oilen_US
dc.titleDietary effect of grape (Vitis vinifera) seed extract mitigates hepatic disorders caused by oxidized fish oil in rainbow trout (Oncorhynchus mykiss)
dc.typeArticle

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