Evaluation of serum endothelial cell-specific molecule-1 levels and carotid intima-media thickness in patients with ankylosing spondylitis

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dc.contributor.authorTurkon, Hakan
dc.contributor.authorGokmen, Ferhat
dc.contributor.authorUysal, Sema
dc.contributor.authorAkbal, Ayla
dc.contributor.authorInceer, Besir Sahin
dc.contributor.authorResorlu, Mustafa
dc.contributor.authorGokmen, Esra
dc.date.accessioned2025-01-27T20:51:58Z
dc.date.available2025-01-27T20:51:58Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Ankylosing spondylitis (AS) is a chronic inflammatory disease and the increased mortality in these patients is largely caused by cardiovascular diseases. Endothelial cell-specific molecule-1 (ESM-1) is a novel marker to assess endothelial dysfunction and expressed by the vascular endothelium. In this study, the serum ESM-1 levels in patients with AS and the possible association between serum ESM-1 and carotid intima-media thickness (CIMT) as a marker of atherosclerosis was evaluated. Methods: A total of thirty-seven patients with AS and thirty healthy control subjects were included in this study. ESM-1, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP) and CIMT were measured in all subjects. ESM-1 levels were measured by ELISA method. The disease activity of patients with AS were assessed using questionnaires Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Results: Serum ESM-1 levels were lower in AS patients than in healthy controls. However, there was no statistically significant difference between ESM-1 levels (304.3 +/- 185.2 vs. 373.9 +/- 206.9 ng/L, respectively; p=0.064). Patients with AS had significantly higher CIMT levels compared with controls (0.77 +/- 0.16 vs. 0.53 +/- 0.09 mm, respectively; p<0.001). While a statistically significant positive correlation was detected in all subjects between CIMT levels and ESR, CRP (r=0.378, p=0.002, r=0.547, p<0.001, respectively), no significant correlation was detected between serum ESM-1 levels and ESR, CRP, BASDAI, BASFI and CIMT. Conclusion: The results showed that CIMT values in AS patients were increased when compared to control group. There was no correlation among ESM-1 levels, disease activity and CIMT. In order to reveal the pathological role of the ESM-1 levels in patients with AS need more studies.
dc.identifier.doi10.1515/tjb-2016-0004
dc.identifier.endpage25
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84958225202
dc.identifier.scopusqualityQ3
dc.identifier.startpage19
dc.identifier.trdizinid199714
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0004
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/199714
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25607
dc.identifier.volume41
dc.identifier.wosWOS:000376238200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAnkylosing spondylitis
dc.subjectendothelial cell-specific molecule-1
dc.subjectcarotid intima-media thickness
dc.subjectCRP
dc.titleEvaluation of serum endothelial cell-specific molecule-1 levels and carotid intima-media thickness in patients with ankylosing spondylitis
dc.title.alternativeAnkilozan spodilitli hastalarda serum endothelial cell-specific molecule-1 ve karotis intima media kalınlığının değerlendirilmesi
dc.typeArticle

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