Synthesis of SMZ derivatives and investigation of effects on germination, root, and plant growth of Arabidopsis thaliana L.

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dc.authoridTaşkın, Kemal Melih / 0000-0002-3746-0508
dc.authoridGüngör, Tuğba / 0000-0001-5261-1856
dc.authoridÖzbilen, Aslıhan / 0000-0002-2034-4682
dc.authoridAy, Mehmet / 0000-0002-1095-1614
dc.authoridCömert Önder, Ferah / 0000-0002-4037-1979
dc.authoridSezer, Fatih / 0000-0002-9436-0191
dc.contributor.authorGüngör, Tuğba
dc.contributor.authorCömert Önder, Ferah
dc.contributor.authorSezer, Fatih
dc.contributor.authorÖzbilen, Aslıhan
dc.contributor.authorTaşkın, Kemal Melih
dc.contributor.authorAy, Mehmet
dc.date.accessioned2025-01-27T21:00:27Z
dc.date.available2025-01-27T21:00:27Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA series of sulfonamide derivatives were synthesized by reactions with various functional groups containing benzenesulfonyl chlorides and aniline derivatives under different substitution reaction conditions. The structures of SMZ derivatives were confirmed with melting point, FT-IR, H-1 NMR, C-13 NMR, and LC-MS/MS techniques. In order to investigate the cytotoxic effects of these derivatives, we used a model plant species. The synthesized compounds (S1-S5) and sulfamethazine (SMZ) as a positive control were applied to Arabidopsis thaliana seeds. Our results indicated that S3 and S4 induced shorter roots and lower wet weight in plants. Plants treated with S2 and S5 showed no growth effects, similar to the untreated control group, while S1 slightly reduced root length and wet weight. These results suggest that S3 and the newly synthesized S4 derivatives have potential for use as herbicides since they possess cytotoxic effects on A. thaliana plants.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [110T754]
dc.description.sponsorshipA part of this study was financially supported by a research grant from the Scientific and Technological Research Council of Turkey (TUBITAK Grant No. 110T754).
dc.identifier.doi10.3906/kim-1901-27
dc.identifier.endpage+
dc.identifier.issn1300-0527
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85071882380
dc.identifier.scopusqualityQ3
dc.identifier.startpage1123
dc.identifier.trdizinid335931
dc.identifier.urihttps://doi.org/10.3906/kim-1901-27
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/335931
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27026
dc.identifier.volume43
dc.identifier.wosWOS:000478961000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSMZ derivatives
dc.subjectArabidopsis thaliana L.
dc.subjectherbicide
dc.subjectsulfonamide
dc.subjectsynthesis
dc.titleSynthesis of SMZ derivatives and investigation of effects on germination, root, and plant growth of Arabidopsis thaliana L.
dc.typeArticle

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