Slightly degradable, naturally antibacterial hydrogel matrixes derived from polyvinyl alcohol and linear/branched-polyethyleneimine as a wound dressing material

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dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridAri, Betül / 0000-0003-3557-3055
dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.contributor.authorAri, Betül
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorDemirci, Şahin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:45:32Z
dc.date.available2025-01-27T20:45:32Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPVA:PEI based film gels were prepared at various weight ratios, 10-100% of linear-PEI (L-PEI) and branched-PEI (B-PEI) to PVA as PVA:L-PEI or PVA:B-PEI to demonstrate the effect of PEI types on hydrolytic degradation, blood compatibility, antibacterial properties, and cytotoxicity. The hydrolytic degradation studies, done at similar to skin pH, 5.4 and revealed that PVA:PEI-based film gels, 1:0.1 wt% are degradable with a gravimetric weight losses of16.80 +/- 1.39% and 17.20 +/- 1.21% up to 7 days, and decreased as the wt% of L-PEI and B-PEI were increased in the matrix. The blood compatibility assays done through hemolysis and blood clotting tests disclosed only PVA:B-PEI film gels at 1.0 mg/mL concentration were found blood compatible. The antimicrobial studies revealed that regardless of the types and weight ratio of L-PEI or B-PEI, all PVA:L-PEI and PVA:B-PEI based film gels possess a potent antibacterial activity against Pseudomonas aeruginosa, a gram-negative bacteria and Staphylococcus aureus, a gram-positive bacteria. Moreover, the cytotoxicity test results examined on the L929 cell line uncovered that only PVA:L-PEI and PVA:B-PEI even at very low concentrations of L-PEI or B-PEI, for example, PVA:L-PEI and PVA:B-PEI at 1:0.1 weight ratio film gel at 10 mg/mL show toxic effect, for example <50% cell viability suggesting lesser concentration use in biomedical applications.
dc.identifier.doi10.1080/10601325.2024.2349953
dc.identifier.endpage453
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85193027360
dc.identifier.scopusqualityQ2
dc.identifier.startpage441
dc.identifier.urihttps://doi.org/10.1080/10601325.2024.2349953
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24615
dc.identifier.volume61
dc.identifier.wosWOS:001221590500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPVA:PEI-based cryogels & film gels
dc.subjectwound dressing material
dc.subjectslightly degradable materials
dc.subjectantibacterial PVA:PEI-based film gels
dc.titleSlightly degradable, naturally antibacterial hydrogel matrixes derived from polyvinyl alcohol and linear/branched-polyethyleneimine as a wound dressing material
dc.typeArticle

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