The relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study

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dc.authoridTURK, UGUR ONSEL/0000-0001-6348-6616
dc.authoridErcan, Ertugrul/0000-0003-0480-4738
dc.contributor.authorTengiz, Istemihan
dc.contributor.authorTurk, Ugur Onsel
dc.contributor.authorAlioglu, Emin
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorTamer, Gulden S.
dc.contributor.authorTuzun, Nurullah
dc.contributor.authorErcan, Ertugrul
dc.date.accessioned2025-01-27T20:51:58Z
dc.date.available2025-01-27T20:51:58Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: NT-pro-brain natriuretic peptide (NT-proBNP) has been shown to be an accurate diagnostic marker in patients with heart failure (HF). Adiponectin (Adp) levels are increased in HF but its diagnostic value is still uncertain in these patients. The study was designed to investigate the possible association of these markers in non-cachectic patients with newly diagnosed systolic heart failure. Methods: Fifty-seven systolic HF patients and 20 matched controls were enrolled in an observational cross-sectional study. Physical and echocardiographic examinations were performed and serum Adp, NT-proBNP, tumor necrosis factor-alpha (TNF-alpha) levels were measured. Study variables were compared between the groups. Correlation analyses were done and the diagnostic validity of the markers was compared with ROC analysis. Results: Adp and NT-proBNP levels were significantly higher in HF group (20.19 +/- 12.9 vs. 7.65 +/- 4.6 mu g/mL; p<0.001 and 1051.74 +/- 606.2 vs. 222.53 +/- 65.6 pg/mL; p=0.002; respectively). TNF-alpha levels were similar between the groups (2.83 +/- 1.8 vs. 2.08 +/- 1.2 pg/mL; p=0.582). Correlation analysis showed significant association among Adp and NT-proBNP levels, (r=0.448; p<0.001), and left ventricular ejection fraction (LVEF) values (r=-0.466; p<0.001). The Adp and NT-proBNP showed comparable diagnostic performances with mean [95% confidence interval] areas under the curves of 0.857 (0.771-0.944) and 0.888 (0.815-0.960), respectively. Conclusion: There were significant correlation between Adp levels with NT-proBNP levels and LVEF values but no any association between Adp levels with body mass index values and TNF-alpha levels in patients with newly diagnosed systolic heart failure. The result may arouse suspicion about the hypothesis, which proposes that Adp levels simply reflects disease severity or cardiac cachexia in patients with HF.
dc.identifier.doi10.5152/akd.2013.067
dc.identifier.endpage226
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3
dc.identifier.pmid23376650
dc.identifier.scopus2-s2.0-84877623056
dc.identifier.scopusqualityN/A
dc.identifier.startpage221
dc.identifier.trdizinid155363
dc.identifier.urihttps://doi.org/10.5152/akd.2013.067
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/155363
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25605
dc.identifier.volume13
dc.identifier.wosWOS:000319806100010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHeart failure
dc.subjectadiponectin
dc.subjectNT-ProBNP
dc.subjectcardiac cachexia
dc.subjectdiagnostic accuracy
dc.titleThe relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study
dc.title.alternativeKaşektik olmayan sistolik kalp yetmezlikli olgularda adiponektin, NT-pro-BNP ve sol ventrikül ejeksiyon fraksiyonu arasındaki ilişki: Gözlemsel bir çalışma
dc.typeArticle

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