A Novel Approach for Arteriovenous Fistula Maturation; Effects of Melatonin Loaded PLGA Nanofibers in Rats

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dc.authorid0000-0001-7557-0268
dc.authorid0000-0003-1654-6406
dc.contributor.authorAykora, Damla
dc.contributor.authorSahin, Serpil
dc.contributor.authorAydeger, Cemre
dc.contributor.authorYulek, Ozden
dc.contributor.authorAlkan, Sevil
dc.contributor.authorOral, Ayhan
dc.contributor.authorJajere, Muhammad Umar
dc.date.accessioned2026-02-03T11:59:43Z
dc.date.available2026-02-03T11:59:43Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Arteriovenous fistula (AVF) is a cannulation method that is accessed by a peripheric vein and an artery. AVF provides vascular access for chronic kidney disease patients so they can receive hemodialysis. AVF could be created by surgical intervention and facilitates arterial to venous circulation for rapid recovery. However, AVF maturation depends on venous proliferation and luminal diameter which allows the optimum flow rate for continuing circiulation and hemodialysis. Due to multiple unexpected conditions, non-maturation of AVFs limits the efficacy of the hemodialysis so patients must receive another surgery for AVF cannulation. Materials and Methods: In this study, we aimed to utilize the effects of melatonin (MT), which is known to have antioxidant, anti-inflammatory, and antiapoptotic effects, to provide longer and more effective use of AVFs via a novel technique. For this purpose, firstly by electrospinning method, polylactic-co-glycolic acid (PLGA) nanofiber membranes were developed. After MT is loaded into the PLGA and characterized. Biodegradation and drug release profiles were analyzed. An in vivo study was performed in Wistar Albino male rats (n=18). Rats were randomly divided into three experimental groups; Sham, PLGA, and MT/PLGA respectively (n=6). AVF model was established in all groups between arteria carotica and vena jugularis under general anesthesia. The Sham group did not receive any treatment or biomaterial application. The developed membranes were placed onto the AVFs in PLGA and MT/PLGA groups. All rats were sacrificed on the 28th of the experiment. The anastomosis sites of all animals were harvested for histopathological analysis. Results: Our results showed MT/PLGA group indicated increased maturation levels conmpared to Sham group (p<0.05). Conclusion: The results showed that PLGA/MEL may be a promising material for early AVF maturation.
dc.identifier.doi10.4274/nkmj.galenos.2025.58966
dc.identifier.endpage148
dc.identifier.issn2587-0262
dc.identifier.issue2
dc.identifier.startpage141
dc.identifier.trdizinid1325973
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2025.58966
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1325973
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34394
dc.identifier.volume13
dc.identifier.wosWOS:001532231600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofNamik Kemal Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectArteriovenous fistula
dc.subjectmelatonin
dc.subjectPLGA
dc.subjectbiocompatible materials
dc.subjectmaturation
dc.subjectvenous proliferati
dc.titleA Novel Approach for Arteriovenous Fistula Maturation; Effects of Melatonin Loaded PLGA Nanofibers in Rats
dc.typeArticle

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