Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial

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dc.authoridŞeydanur Dengizek, Eltas / 0000-0002-7640-551X
dc.authoridAbubekir, Eltas / 0000-0001-9300-4091
dc.contributor.authorŞeydanur Dengizek, Eltas
dc.contributor.authorSerkan, Dündar
dc.contributor.authorAbubekir, Eltas
dc.contributor.authorKarabulut Bay, Aysun
dc.contributor.authorÖnder, Otlu
dc.contributor.authorArife, Çiçek
dc.date.accessioned2025-01-27T21:02:17Z
dc.date.available2025-01-27T21:02:17Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-beta) levels were evaluated from saliva samples. Results: Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-beta levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05). Conclusion: The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.
dc.description.sponsorshipScientific Research Project Fund of Inonu University [2011/73]
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Inonu University (2011/73).
dc.identifier.doi10.1590/1678-7757-2018-0108
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.pmid30673028
dc.identifier.scopus2-s2.0-85060387406
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1590/1678-7757-2018-0108
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27326
dc.identifier.volume27
dc.identifier.wosWOS:000456079700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Sao Paulo Fac Odontologia Bauru
dc.relation.ispartofJournal of Applied Oral Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectChronic periodontitis
dc.subjectInflammation
dc.subjectOzone
dc.subjectPeriodontal treatment
dc.subjectTGF-beta
dc.titleEvaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial
dc.typeArticle

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