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Öğe Titanium platelet-rich fibrin (T-PRF) as high-capacity doxycycline delivery system(Springer Heidelberg, 2022) Ercan, Esra; Sağbaş Suner, Selin; Sılan, Coşkun; Yılmaz, Selehattin; Sıddıkoğlu, Duygu; Şahiner, Nurettin; Tunalı, MustafaObjectives Titanium platelet-rich fibrin (T-PRF), a second-generation autogenous blood concentrate with tough and thick fibrin meshwork activated by a titanium tube, was used as a drug carrier for doxycycline (Doxy) by injection. The objective of this study is to evaluate the loading capacity of T-PRF, release kinetics of doxycycline-loaded T-PRF, and its antibacterial effects against S. aureus and P. aeruginosa. Materials and methods The T-PRF and collagen were loaded with Doxy as T-PRF/Doxy and Collagen/Doxy, and their release and antibacterial activities against S. aureus and P. aeruginosa were investigated. Chemical characterization and morphological analysis were performed. Results In comparison with collagen, approximately sevenfold more Doxy, 281 mg/g, was loaded into T-PRF. It was found that 25% of the loaded Doxy was released from T-PRF compared to only 12% from collagen within 72 h. The largest inhibition zone diameter (IZD) was observed for T-PRF/Dox with 32 +/- 6 mm and 37 +/- 5 mm for P. aereginosa and S. aureus, respectively. However, only 10 +/- 5 mm and 10 +/- 6 mm IZD were observed for bare T-PRF, and no inhibition zone was observed for the Collagen/Doxy group. A dense fibrin structure was visualized on SEM images of the T-PRF/Doxy group compared to the T-PRF group. Conclusions T-PRF has higher Doxy loading capacity and long-acting antibacterial effects compared to collagen. T-PRF was shown to have potential autogenous long-term drug-carrying capability for doxycycline. Also, the potential fibrinophilic properties of Doxy were observed to strengthen the structure of T-PRF.Öğe Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial(Faculdade De Odontologia De Bauru, 2021) Sağlam, Ebru; Özsağır, Zeliha Betül; Ünver, Tuğba; Alınca, Suzan Bayer; Toprak, Ali; Tunalı, MustafaObjective: Our study compared the effects of injectable platelet-rich fibrin (i-PRF) with those of corticosteroids in the treatment of erosive oral lichen planus (EOLP). Methodology: This split-mouth study included 24 individuals diagnosed histopathologically with bilateral EOLP. One bilateral lesion was injected with i-PRF, whereas the other was injected with methylprednisolone acetate in four sessions at 15-day intervals. Visual analog scale (VAS) for pain and satisfaction, oral health impact profile scale-14, and the lesion size were used. Results: The intragroup comparisons showed a significant decrease in VAS-pain and lesion size in both the i-PRF group (from 81.88 +/- 17.74 to 13.33 +/- 18.34, and from 4.79 +/- 0.41 to 1.88 +/- 1.08, respectively) and the corticosteroid group (from 80.21 +/- 17.35 to 23.33 +/- 26.81, and from 4.71 +/- 0.46 to 2.21 +/- 1.35, respectively) in the 6th month compared to baseline (p<0.001). Moreover, VAS-satisfaction increased significantly in both the i-PRF group (from 26.67 +/- 17.8 to 85.63 +/- 16.24) and the corticosteroid group (from 28.33 +/- 17.05 to 74.38 +/- 24.11) in the 6th month compared to baseline (p<0.001). However, no significant difference in any value occurred in the intergroup comparisons. Conclusion: In patients with EOLP, both methods decreased pain and lesion size similarly, and both increased satisfaction. Therefore, the use of i-PRF may be considered an option in cases refractory to topical corticosteroid therapy. Biochemical and histopathological studies are required to reveal the mechanism of i-PRF action in EOLP treatment.Öğe Effects of titanium prepared platelet rich fibrin on facial nerve regeneration: an experimental study([Brazilian Association of Otorhinolaryngology and Cervico-Facial Surgery], 2022) Şentürk, Fatma; Bahadır, Osman; Aktaş, Osman; Bıyık, Ayşe Firuze; Ercan, EsraIntroduction: Facial nerve damage is a condition that causes functional, psychological, and cosmetic problems; and treatment methods need to be improved. Objective: We investigated the efficacy of titanium-prepared platelet-rich fibrin as a healing enhancer at the region of transection of the facial nerve. Methods: Twenty-seven New Zealand male rabbits were used in this study, divided into three experimental groups. Group 1, the sham group (n = 7); Group 2, the suture group (n = 10); and Group 3, the suture + T-PRF group (n = 10). In Group 1, the facial nerve trunk was dissected, and no additional surgical intervention was performed. For Group 2, a transection was made to the facial nerve trunk and the nerve endings were sutured together. In Group 3, nerve endings were sutured after transection, and a titanium-prepared platelet-rich fibrin membrane was wrapped in a tube around the damaged area. All animals were followed up weekly for the presence of corneal reflex, whisker movement and low ears. Bilateral facial electromyography was performed both preoperatively and postoperatively at the 1st, 3rd, 5th, 7th, 10th weeks. Tissue samples obtained at the 10th week were histopathologically examined, and intra-group and inter-group comparisons were performed. Results: Subjects in Group showed improvement in whisker movement and ear drop one week earlier than Group 2. In Group 3, the nerve stimulation threshold required to trigger the compound muscle action potential had returned to values similar to the preoperative control values (11.31 ± 2.16 V) by 5 weeks postoperatively (12.51 ± 3.97 V), (p = 0.249). Conclusion: Titanium-prepared platelet-rich fibrin administration contributed to partial nerve healing both on a functional and an electrophysiological level.Öğe Evaluation of children with disabilities: BMI indicators and difficulties experienced by parents Evaluation of disabled children(Bayrakol Medical Publishing, 2021) Çağ, Yakup; Tunalı, Esra; Ataş, Cafer; Orhan, Ahmet Lutfullah; Tunalı, Mustafa; Özen, BuğraAim: The aim of this study was to analyze the disability categories and sociodemographic characteristics of disabled children to stratify their risks in terms of body mass index (BMI), obesity and underweight, and to identify the problems of affected children and their families.Material and Methods: A total of 1229 children younger than 7 years of age were identified to be surveyed with home visits by a dedicated team. BMI param-eters were obtained for 330 children. Functional impairment was classified into six groups according to the ICD-10 (International Statistical Classification of Diseases and Related Health Problems) codes.Results: Children with orthopedic disabilities accounted for 34.9%, with intellectual disability 34.1%, developmental disorders of speech and language 15.6%, autistic disorders 15.5%, hearing loss 8%, and visual disturbances and blindness 0.8%.According to the BMI percentile curves of the 330 children, 25.8% were considered obese, 5.4% were overweight, and 18.5% were underweight. The risks for obesity and underweight were significantly increased in children with autistic disorders and orthopedic disabilities, respectively (p<0.05). Discussion: Children with disabilities are at an increased risk for obesity and underweight, which requires the evaluation and close monitoring of nutritional problems and provision of nutritional support.Öğe Effect of Passive Tobacco Smoking Exposure on the Periodontal Status of Turkish Children(Faculty of Dentistry, Universitas Indonesia, 2021) Alan, Raif; Gezgin, Onur; Korkut, Emre; Türkoğlu, Şükriye; Çelik, Esra; Haliloğlu, SeyfullahObjective: This study aimed to assess the effect of passive tobacco smoking (PTS) through the comparison of the periodontal status and the C-reactive protein (CRP) and cotinine levels in the biologic fluids in children who are exposed and unexposed to PTS. Methods: A total of 148 participants, whom had smokers (PTS-exposed, n=82) and non-smokers (PTS-unexposed, n=66) in their families, respectively, were included in the study. Gingival index, plaque index, probing depth, and bleeding on probing were recorded. Moreover, saliva, urine, and gingival crevicular fluid samples were collected. CRP and cotinine levels in the biological fluids were determined by the enzyme-linked immunosorbent assay method. Results: Both groups exhibited similar values for periodontal parameters and salivary CRP levels were higher in PTS-exposed group but not significant. The mean urinary cotinine level was significantly higher in children exposed to PTS than in unexposed children. Conclusions: There was no evidence for causative role of PTS in periodontal disease in this study. Longitudinal studies including large populations should be conducted to provide stronger evidence for the causative role of PTS in periodontal disease. Also, further epidemiological studies on the social context of smoking should be performed to improve the quality of life and lifespan of the society.
