Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action

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dc.authorid0000-0002-1740-4867en_US
dc.authorscopusid22136607900en_US
dc.authorwosidEBN-0588-2022en_US
dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorQuispe, Cristina
dc.contributor.authorRahavian, Amirhossein
dc.contributor.authorPereira Carneiro, Joara Nalyda
dc.contributor.authorRocha, Janaina Esmeraldo
dc.contributor.authorAlves Borges Leal, Antonio Linkoln
dc.contributor.authorBoyuneğmez Tümer, Tuğba
dc.date.accessioned2023-07-11T10:19:45Z
dc.date.available2023-07-11T10:19:45Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractSexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative review aims to present updated information about the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections. A search of the literature was performed using databases and search engines such as PubMed, Scopus, Google Scholar and Science Direct. From the pharmacotherapeutic management point of view, any strategies for prevention should contain medical approaches. The bioactive compounds obtained from natural products have shown biological effects against different microorganisms for the treatment of these diseases. The main results showed antimicrobial, antiprotozoal, antifungal and antiviral effects such as HIV. Also, the molecular mechanisms, signalling pathways and action targets of natural compounds were highlighted, thus justifying bacterial and antifungal inhibition, apoptosis or reduction of viral replication. From the data of our study, we can conclude that natural compounds may be a significant source for adjuvant drugs / complementary therapies in the treatment of STDs. With all these benefits, the future must conduct extensive clinical trials and the development of pharmaceutical nanotechnologies for a greater therapeutic effect.en_US
dc.identifier.citationSharifi-Rad, J., Quispe, C., Rahavian, A., Pereira Carneiro, J. N., Rocha, J. E., Alves Borges Leal, A. L., . . . Calina, D. (2021). Bioactive compounds as potential agents for sexually transmitted diseases management: A review to explore molecular mechanisms of action. Frontiers in Pharmacology, 12 doi:10.3389/fphar.2021.674682en_US
dc.identifier.doi10.3389/fphar.2021.674682
dc.identifier.issn1663-9812
dc.identifier.pmid34504422
dc.identifier.scopus2-s2.0-85114431688
dc.identifier.urihttps://doi.org/10.3389/fphar.2021.674682
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4364
dc.identifier.volume12en_US
dc.identifier.wosWOS:000695875900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBoyuneğmez Tümer, Tuğba
dc.language.isoen
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Pharmacologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectClinical studiesen_US
dc.subjectMechanismsen_US
dc.subjectMolecular targetsen_US
dc.subjectNatural compoundsen_US
dc.subjectPathogensen_US
dc.subjectPharmacological effectsen_US
dc.subjectSexually transmitted diseases (STDs)en_US
dc.titleBioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action
dc.typeReview Article

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