Exploring the diverse biological significance and roles of fucosylated oligosaccharides

Basit Öğe Kaydı
dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.authoridPekdemir, Burcu / 0000-0003-4566-8015
dc.contributor.authorPekdemir, Burcu
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-01-27T20:38:38Z
dc.date.available2025-01-27T20:38:38Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractLong since, carbohydrates were thought to be used just as an energy source and structural material. However, in recent years, with the emergence of the field of glycobiology and advances in glycomics, much has been learned about the biological role of oligosaccharides, a carbohydrate polymer containing a small number of monosaccharides, in cell-cell interaction, signal transduction, immune response, pathogen adhesion processes, early embryogenesis, and apoptosis. The function of oligosaccharides in these processes is diversified by fucosylation, also known as modification of oligosaccharides. Fucosylation has allowed the identification of more than 100 different oligosaccharide structures that provide functional diversity. ABO blood group and Lewis antigens are among the best known fucosyl-linked oligosaccharides. In addition, the antigens in the ABO system are composed of various sugar molecules, including fucosylated oligosaccharides, and Lewis antigens are structurally similar to ABO antigens but differ in the linkage of sugars. Variation in blood group antigen expression affects the host's susceptibility to many infections. However, altered expression of ABO and Lewis antigens is related with prognosis in carcinoma types. In addition, many pathogens recognize and bind to human tissues using a protein receptor with high affinity for the fucose molecule in glycoconjugates, such as lectin. Fucosylated oligosaccharides also play vital roles during fertilization and early embryogenesis. Learning and memory-related processes such as neurite growth, neurite migration, and synapse formation seen during the development of the brain, which is among the first organs to develop in embryogenesis, are regulated by fucosylated oligosaccharides. In conclusion, this review mentions the vital roles of fucosylated oligosaccharides in biology, drawing attention to their importance in the development of chemical tools to be used in function analysis and the investigation of various therapeutic targets.
dc.identifier.doi10.3389/fmolb.2024.1403727
dc.identifier.issn2296-889X
dc.identifier.pmid38863964
dc.identifier.scopus2-s2.0-85195553222
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fmolb.2024.1403727
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23684
dc.identifier.volume11
dc.identifier.wosWOS:001242885300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Molecular Biosciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectfucose
dc.subjectfucosylation
dc.subjectglycoconjugates
dc.subjectfucosylated oligosaccharides
dc.subjectfucosyltransferases
dc.subjectmodifications
dc.titleExploring the diverse biological significance and roles of fucosylated oligosaccharides
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Sercan Karav_Review Article.pdf
Boyut:
771.56 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu