Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases

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dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorAbolfazli, Sajad
dc.contributor.authorKarav, Sercan
dc.contributor.authorJohnston, Thomas P.
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2025-05-29T02:58:02Z
dc.date.available2025-05-29T02:58:02Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCardiovascular illnesses are multifactorial disorders and represent the primary reasons for death worldwide, according to the World Health Organization. As a signaling molecule, nitric oxide (NO) is extremely permeable across cellular membranes owing to its unique molecular features, like its small molecular size, lipophilicity, and free radical properties. Some of the biological effects of NO are vasodilation, inhibition in the growth of vascular smooth muscle cells, and functional regulation of cardiac cells. Several therapeutic approaches have been tested to increase the production of NO or some downstream NO signaling pathways. The health benefits of red wine are typically attributed to the polyphenolic phytoalexin, resveratrol (3,5,4 '-trihydroxy-trans-stilbene), which is found in several plant species. Resveratrol has beneficial cardiovascular properties, some of which are mediated through endothelial nitric oxide synthase production (eNOS). Resveratrol promotes NO generation from eNOS through various methods, including upregulation of eNOS expression, activation in the enzymatic activity of eNOS, and reversal of eNOS uncoupling. Additionally, by reducing of oxidative stress, resveratrol inhibits the formation of superoxide and inactivation NO, increasing NO bioavailability. This review discusses the scientific literature on resveratrol's beneficial impact on NO signaling and how this effect improves the function of vascular endothelium.
dc.identifier.doi10.1007/s43440-025-00694-w
dc.identifier.endpage374
dc.identifier.issn1734-1140
dc.identifier.issn2299-5684
dc.identifier.issue2
dc.identifier.pmid39832074
dc.identifier.scopus2-s2.0-85217185390
dc.identifier.scopusqualityQ1
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.1007/s43440-025-00694-w
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30250
dc.identifier.volume77
dc.identifier.wosWOS:001400760900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofPharmacological Reports
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectNitric oxide
dc.subjectResveratrol
dc.subjectCardiovascular diseases
dc.subjectNitric oxide bioavailability
dc.titleRegulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases
dc.typeReview

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