Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency

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dc.authoridSılan, Fatma/0000-0001-7191-2240
dc.authoridPASA, SEMIR/0000-0001-8029-7622
dc.contributor.authorDemir, Bulent
dc.contributor.authorDemir, Sureyya Saridas
dc.contributor.authorKaracaer, Kubra Ozkan
dc.contributor.authorPasa, Semir
dc.contributor.authorSılan, Fatma
dc.date.accessioned2025-01-27T20:47:26Z
dc.date.available2025-01-27T20:47:26Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: In most of primary ovarian insufficiency (POI) cases, etiologic factors have not been fully elucidated. Recent studies have revealed that inflammatory agents play an important role in the etiopathogenesis of POI. Therefore, the aim of this study was to investigate the role of inflammatory markers of hemogram parameters in POI. Materials and Methods: The study compared 47 healthy women and 47 women diagnosed as having POI retrospectively by scanning electronic and written recording systems. Complete blood counts, day-3 hormone profiles levels of all subjects were analyzed. The neutrophil-lymphocyte ratio (NLR), red cell distribution width (RDW), platelet ratio (RPR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) mean platelet lymphocyte ratio (MPLR) were calculated from the complete blood count parameters. Results: White blood cell and MPV values, platelet, and lymphocyte counts were significantly higher in the POI patients (p<0.001, p=0.042, p=0.038, p=0.049, respectively), RPR was significantly lower than the control group (p=0.011), but there were no significant differences in hemoglobin, RDW, NLR, PLR, and MPLR (p=0.454, p=0.057, p=0.635, p=0.780, p=0.126, respectively). The neutrophil count of the study group was higher than in the control group (p=0.057). Bivariate correlation analyses showed no correlations between blood parameters and hormone levels. The area under the receiver operating characteristic curve for RPR in POI was 0.652, with a threshold value 0.053, sensitivity=63% and specificity=63. Conclusion: Inflammatory markers of hemogram detected higher in patients with POI then control subjects.
dc.identifier.doi10.4274/tjod.galenos.2019.09476
dc.identifier.endpage14
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue1
dc.identifier.pmid32341824
dc.identifier.scopus2-s2.0-85084813295
dc.identifier.scopusqualityQ3
dc.identifier.startpage9
dc.identifier.trdizinid427722
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2019.09476
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/427722
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24905
dc.identifier.volume17
dc.identifier.wosWOS:000523674600002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPrimary ovarian insufficiency
dc.subjectinflammation
dc.subjecthemogram
dc.titleEvaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency
dc.title.alternativePrimer ovaryen yetersizlik hastalarında hemogramdaki enflamatuvar parametrelerin değerlendirilmesi
dc.typeArticle

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