Up-to-date on the evidence linking miRNA-related epitranscriptomic modifications and disease settings. Can these modifications affect cross-kingdom regulation?

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dc.authorid0000-0002-2014-6635en_US
dc.authorscopusid22733342800en_US
dc.authorwosid-en_US
dc.contributor.authorTome-Carneiro, Joao
dc.contributor.authorLopez de las Hazas, Maria-Carmen
dc.contributor.authorBoughanem, Hatim
dc.contributor.authorBottcher, Yvonne
dc.contributor.authorCayir, Akin
dc.contributor.authorMacias Gonzalez, Manuel
dc.contributor.authorDavalos, Alberto
dc.date.accessioned2022-06-30T12:22:15Z
dc.date.available2022-06-30T12:22:15Z
dc.date.issued2021en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractThe field of epitranscriptomics is rapidly developing. Several modifications (e.g. methylations) have been identified for different RNA types. Current evidence shows that chemical RNA modifications can influence the whole molecule's secondary structure, translatability, functionality, stability, and degradation, and some are dynamically and reversibly modulated. miRNAs, in particular, are not only post-transcriptional modulators of gene expression but are themselves submitted to regulatory mechanisms. Understanding how these modifications are regulated and the resulting pathological consequences when dysregulation occurs is essential for the development of new therapeutic targets. In humans and other mammals, dietary components have been shown to affect miRNA expression and may also induce chemical modifications in miRNAs. The identification of chemical modifications in miRNAs (endogenous and exogenous) that can impact host gene expression opens up an alternative way to select new specific therapeutic targets. Hence, the aim of this review is to briefly address how RNA epitranscriptomic modifications can affect miRNA biogenesis and to summarize the existing evidence showing the connection between the (de)regulation of these processes and disease settings. In addition, we hypothesize on the potential effect certain chemical modifications could have on the potential cross-kingdom journey of dietary plant miRNAs.en_US
dc.identifier.citationTomé-Carneiro, J., de Las Hazas, M.-C. L., Boughanem, H., Böttcher, Y., Cayir, A., Macias González, M., & Dávalos, A. (2021). Up–to–date on the evidence linking miRNA-related epitranscriptomic modifications and disease settings. Can these modifications affect cross-kingdom regulation? RNA Biology, 18(sup2), 586–599. https://doi.org/10.1080/15476286.2021.2002003 ‌en_US
dc.identifier.doi10.1080/15476286.2021.2002003
dc.identifier.endpage599en_US
dc.identifier.issn1547-6286
dc.identifier.issn1555-8584
dc.identifier.issue2en_US
dc.identifier.pmid34843412
dc.identifier.scopus2-s2.0-85120057840
dc.identifier.startpage586en_US
dc.identifier.urihttps://doi.org/10.1080/15476286.2021.2002003
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3596
dc.identifier.volume18en_US
dc.identifier.wosWOS:000723460100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇayır, Akın
dc.language.isoen
dc.publisherTaylor and Francisen_US
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/CA16120
dc.relation.ispartofRNA Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpitranscriptomicsen_US
dc.subjectmiRNA modificationsen_US
dc.subjectMethylationen_US
dc.subjectM6 Aen_US
dc.subjectCross-kingdomen_US
dc.titleUp-to-date on the evidence linking miRNA-related epitranscriptomic modifications and disease settings. Can these modifications affect cross-kingdom regulation?
dc.typeArticle

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