Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury

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dc.authorid0000-0003-0344-6246en_US
dc.authorscopusid57191676140en_US
dc.authorwosid-en_US
dc.contributor.authorÖzçiçek, İlyas
dc.contributor.authorAyşit, Neşe
dc.contributor.authorBalçıkanlı, Zeynep
dc.contributor.authorUlaş Aytürk, Nilufer
dc.contributor.authorAydeğer, Asel
dc.contributor.authorBaydaş, Gülsena
dc.date.accessioned2024-02-10T09:45:38Z
dc.date.available2024-02-10T09:45:38Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractSpinal cord injuries are very common worldwide, leading to permanent nerve function loss with devastating effects in the affected patients. The challenges and inadequate results in the current clinical treatments are leading scientists to innovative neural regenerative research. Advances in nanoscience and neural tissue engineering have opened new avenues for spinal cord injury (SCI) treatment. In order for designed nerve guidance conduit (NGC) to be functionally useful, it must have ideal scaffold properties and topographic features that promote the linear orientation of damaged axons. In this study, it is aimed to develop channeled polycaprolactone (PCL)/Poly-D,L-lactic-co-glycolic acid (PLGA) hybrid film scaffolds, modify their surfaces by IKVAV pentapeptide/gold nanoparticles (AuNPs) or polypyrrole (PPy) and investigate the behavior of motor neurons on the designed scaffold surfaces in vitro under static/bioreactor conditions. Their potential to promote neural regeneration after implantation into the rat SCI by shaping the film scaffolds modified with neural factors into a tubular form is also examined. It is shown that channeled groups decorated with AuNPs highly promote neurite orientation under bioreactor conditions and also the developed optimal NGC (PCL/PLGA G1-IKVAV/BDNF/NGF-AuNP50) highly regenerates SCI. The results indicate that the designed scaffold can be an ideal candidate for spinal cord regeneration.en_US
dc.identifier.citationÖzçiçek, I., Ayşit, N., Balçıkanlı, Z., Aytürk, N. U., Aydeğer, A., Baydaş, G., … Erim, U. C. (2024). Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury. Macromolecular Bioscience. https://doi.org/10.1002/mabi.202300453en_US
dc.identifier.doi10.1002/mabi.202300453
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.pmid38224015
dc.identifier.scopus2-s2.0-85182451152
dc.identifier.urihttps://doi.org/10.1002/mabi.202300453
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5638
dc.identifier.wosWOS:001144438200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUlaş Aytürk, Nilufer
dc.language.isoen
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/119S141
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGold nanoparticlesen_US
dc.subjectNerve guidance conduiten_US
dc.subjectNeural tissue engineeringen_US
dc.subjectNeuronal regenerationen_US
dc.subjectPolycaprolactone/poly-lactic-glycolic aciden_US
dc.subjectSpinal cord injuryen_US
dc.titleDevelopment of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury
dc.typeArticle

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