Synthesis of Functionalized Novel ?-Amino-?-alkoxyphosphonates through Regioselective Ring Opening of Aziridine-2-phosphonates

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dc.contributor.authorPolat-Cakir, Sidika
dc.contributor.authorBeksultanova, Nurzhan
dc.contributor.authorDogan, Ozdemir
dc.date.accessioned2025-01-27T20:14:42Z
dc.date.available2025-01-27T20:14:42Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAziridines are highly useful compounds as building blocks for the synthesis of important organic compounds. Amino acid synthesis by aziridine ring opening reaction is a good example to the use of aziridines. Although this reaction is studied by many groups, the synthesis of amino phosphonic acids is less explored. In this study, we have carried out the ring opening reaction of aziridinyl phosphonates with a variety of alcohols including the more functional propargylic and allylic alcohols. These reactions provided functionalized alpha-amino-beta-alkoxyphosphonates in 40-91 % yield.
dc.description.sponsorshipMiddle East Technical University (METU)
dc.description.sponsorshipWe thank the Middle East Technical University (METU) for the financial support.
dc.identifier.doi10.1002/hlca.201900199
dc.identifier.issn0018-019X
dc.identifier.issn1522-2675
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85074843232
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/hlca.201900199
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21176
dc.identifier.volume102
dc.identifier.wosWOS:000495140600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofHelvetica Chimica Acta
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectaziridine-2-phosphonates
dc.subjectnucleophilic ring opening
dc.subjectalpha-amino-beta-alkoxyphosphonates
dc.titleSynthesis of Functionalized Novel ?-Amino-?-alkoxyphosphonates through Regioselective Ring Opening of Aziridine-2-phosphonates
dc.typeArticle

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