Synthesis of Functionalized Novel ?-Amino-?-alkoxyphosphonates through Regioselective Ring Opening of Aziridine-2-phosphonates
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aziridines are highly useful compounds as building blocks for the synthesis of important organic compounds. Amino acid synthesis by aziridine ring opening reaction is a good example to the use of aziridines. Although this reaction is studied by many groups, the synthesis of amino phosphonic acids is less explored. In this study, we have carried out the ring opening reaction of aziridinyl phosphonates with a variety of alcohols including the more functional propargylic and allylic alcohols. These reactions provided functionalized alpha-amino-beta-alkoxyphosphonates in 40-91 % yield.
Açıklama
Anahtar Kelimeler
aziridine-2-phosphonates, nucleophilic ring opening, alpha-amino-beta-alkoxyphosphonates
Kaynak
Helvetica Chimica Acta
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
102
Sayı
11
