Comparing extracorporeal shock wave and hyaluronic acid in a rabbit cartilage defect model: the effects of ESW on cartilage defect

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dc.authoridOztemur, Zekeriya/0000-0003-2134-8797
dc.contributor.authorOztemur, Zekeriya
dc.contributor.authorOzer, Hatice
dc.contributor.authorGolge, Umut Hatay
dc.contributor.authorAltuntas, Emine Elif
dc.contributor.authorBulut, Okay
dc.date.accessioned2025-01-27T20:54:13Z
dc.date.available2025-01-27T20:54:13Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: To compare the efficiency of extracorporeal shock wave (ESW) treatment with hyaluronic acid (HA) viscosupplementation in an experimental rabbit cartilage defect model. Materials and methods: A total of 24 New Zealand rabbits were randomly divided into 4 groups: HA, ESW, ESW + HA, and control. Chondral defects were created in the left knees of the rabbits. HA viscosupplementation was performed on the HA and ESW + HA groups, and after 24 h, 0.16 mJ/mm2 ESW was performed on the ESW and ESW + HA groups. After an 8-week follow-up, the rabbits were sacrificed and histopathological examination of the defects was carried out. In addition, immunohistochemistry was performed by the avidin-biotin peroxidase method using vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-beta 1), and type II collagen antibodies, and the results were evaluated semiquantitatively. Results: There was a significant difference between the control group and the ESW group in terms of Pineda score and type II collagen expression; between the control group and the HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression; and between the control group and the ESW + HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression. Conclusion: The results show that both treatment methods have positive therapeutic effects on the articular cartilage defect model in terms of the parameters studied.
dc.description.sponsorshipCumhuriyet University Scientific Research Projects (CUBAP) Project [T-421]
dc.description.sponsorshipThe present study was supported by Cumhuriyet University Scientific Research Projects (CUBAP) Project no T-421.
dc.identifier.doi10.3906/sag-1208-2
dc.identifier.endpage492
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84878420336
dc.identifier.scopusqualityQ1
dc.identifier.startpage484
dc.identifier.trdizinid211683
dc.identifier.urihttps://doi.org/10.3906/sag-1208-2
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/211683
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26016
dc.identifier.volume43
dc.identifier.wosWOS:000321481200024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectESW
dc.subjectHA
dc.subjectcartilage defect
dc.subjectVEGF
dc.subjectTGF-beta 1
dc.subjecttype II collagen
dc.titleComparing extracorporeal shock wave and hyaluronic acid in a rabbit cartilage defect model: the effects of ESW on cartilage defect
dc.typeArticle

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