Effects of metformin on lipopolysaccharide induced inflammation by activating fibroblast growth factor 21

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dc.authorid0000-0003-2134-4067en_US
dc.authorscopusid57214228253en_US
dc.authorwosidAAR-1992-2020en_US
dc.contributor.authorKar, Ezgi
dc.contributor.authorAlataş, Özkan
dc.contributor.authorŞahintürk, Varol
dc.contributor.authorÖz, Semih
dc.date.accessioned2023-05-16T07:18:22Z
dc.date.available2023-05-16T07:18:22Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractLipopolysaccharide (LPS) is a component of the cell wall of Gram-negative bacteria that produces endotoxemia, which may cause septic shock. Metformin (MET) is a widely used hypoglycemic drug that exhibits anti-inflammatory properties. Fibroblast growth factor 21 (FGF21) is an endocrine polypeptide that affects glucose and lipid metabolism, and also possesses anti-inflammatory properties. We investigated the effects of MET and FGF21 on inflammation due to LPS induced endotoxemia in male rats. Animals were divided into five groups: control, LPS, pre-MET LPS, LPS + 1 h MET and LPS + 3 h MET. Serum levels of alanine aminotransferase, aspartate aminotransferase, FGF2, interleukin-10 and tumor necrosis factor alpha were measured. Malondialdehyde, myeloperoxidase and FGF21 levels were measured in liver tissue samples. Histopathology of all groups was assessed using hematoxylin and eosin stained sections. LPS caused severe inflammatory liver damage. MET exhibited a partially protective effect and reduced inflammation significantly. FGF21 is produced in the liver following inflammation and MET may increase its production.en_US
dc.identifier.citationKar, E., Alataş, Ö., Şahintürk, V., & Öz, S. (2022). Effects of metformin on lipopolysaccharide induced inflammation by activating fibroblast growth factor 21. Biotechnic and Histochemistry, 97(1), 44-52. doi:10.1080/10520295.2021.1894353en_US
dc.identifier.doi10.1080/10520295.2021.1894353
dc.identifier.endpage52en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid33663305
dc.identifier.scopus2-s2.0-85123393866
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1894353
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4174
dc.identifier.volume97en_US
dc.identifier.wosWOS:000625690900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKar, Ezgi
dc.language.isoen
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofBiotechnic and Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndotoxemiaen_US
dc.subjectFibroblast growth factor 21en_US
dc.subjectInflammationen_US
dc.subjectLipopolysaccharideen_US
dc.subjectMetforminen_US
dc.subjectRatsen_US
dc.titleEffects of metformin on lipopolysaccharide induced inflammation by activating fibroblast growth factor 21
dc.typeArticle

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