Porous and modified HA particles as potential drug delivery systems

Basit Öğe Kaydı
dc.authoridSılan, Coşkun / 0000-0002-8352-6571
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridBütün Şengel, Sultan / 0000-0001-7036-2224
dc.authoridErduğan, Hüseyin / 0000-0002-7047-6640
dc.authoridIlgın, Pınar / 0000-0001-7071-0575
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorSılan, Coşkun
dc.contributor.authorSağbaş, Selin
dc.contributor.authorIlgın, Pınar
dc.contributor.authorBütün, Sultan
dc.contributor.authorErduğan, Hüseyin
dc.contributor.authorAyyala, Ramesh S.
dc.date.accessioned2025-01-27T21:05:25Z
dc.date.available2025-01-27T21:05:25Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractComposite silica-hyaluronic acid (Si-HA) micro particles were synthesized, employing tetraethyl orthosilicate (TEOS) in the presence of linear HA and a crosslinker, divinyl sulfone (DVS) via a water-in-oil microemulsion polymerization technique. Porous HA (PHA) hydrogel particles were generated after removal of silica particles upon treatment of HA composites with hydrofluoric acid (FIF). Furthermore, HA particles were quaternized (QHA) by chemical modification using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride as a quarternization agent. The size of HA based particles were ranged between 1.26 and 2.95 mu m. The PHA particles have a surface area of 2.7 m(2)/g confirmed by the surface area measurements. Modified HA particles were used in the absorption and release studies of two model drugs in PBS, trimethoprim (TMP) and sodium diclofenac (SDF) which are acidic and basic in nature, respectively. The ability to control the size, charge and porosity of the HA particles which showed almost linear drug release profiles. (C) 2012 Elsevier Inc. All rights reserved.
dc.description.sponsorshipScientific and Technical Council of Turkey [108T133]; Turkish Academy of Science (TUBA)
dc.description.sponsorshipThis research is supported by The Scientific and Technical Council of Turkey (Grant No. 108T133). N. Sahiner is also grateful for the financial support by the Turkish Academy of Science (TUBA) under GEBIP-2008 project.
dc.identifier.doi10.1016/j.micromeso.2012.01.027
dc.identifier.endpage130
dc.identifier.issn1387-1811
dc.identifier.scopus2-s2.0-84856985878
dc.identifier.scopusqualityQ1
dc.identifier.startpage124
dc.identifier.urihttps://doi.org/10.1016/j.micromeso.2012.01.027
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27631
dc.identifier.volume155
dc.identifier.wosWOS:000302893400018
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofMicroporous and Mesoporous Materials
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHA microgels
dc.subjectHA composites
dc.subjectPorous HA
dc.subjectModified HA particles
dc.subjectDrug delivery
dc.titlePorous and modified HA particles as potential drug delivery systems
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Nurettin Sahiner_Makale.pdf
Boyut:
1.18 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyoloji Bölümü Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
Kimya Bölümü Koleksiyonu
Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezi Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu