Tetracalcium phosphate treatment on experimental fracture model in rats

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dc.authoridYilmaz, Onur/0000-0001-7515-0300
dc.authoridkaymaz, burak/0000-0001-6207-8063
dc.contributor.authorKaymaz, Burak
dc.contributor.authorYilmaz, Onur
dc.contributor.authorTasova, Ali Osman
dc.contributor.authorAnapa, Dogukan
dc.date.accessioned2025-01-27T20:31:20Z
dc.date.available2025-01-27T20:31:20Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: This study aims to investigate the efficacy of tetracalcium phosphate (TTCP) on fracture healing in rat femurs. Materials and methods: Forty-two female Wistar Albino rats were randomized into two groups (Group 1 and Group 2, n=21 for each). The left femur of all animals was fractured by osteotomy after deep anesthesia with ketamine. Additional procedure was not applied to the rats in Group 1. Rats in Group 2, following osteotomy, were applied to the fracture line approximately 2 mL TTCP. The animals were sacrificed at Weeks 1, 2, and 3 after surgery (seven animals were sacrificed from each group each week) and the broken femurs were removed. The femurs were examined first radiographically and second histopathologically. Results: Radiologically, callus maturity and bone union increased with time in both groups. However, no significant differences were found regarding callus maturity and bone union in weekly comparisons (anteroposterior plain: p=0.53, p=0.37, p=0.42, lateral plain: p=0.26, p=0.42, p=0.87). Histopathologically, the fractures healed normally as the weeks progressed in both groups. The histological scores of Group 2 were higher at Weeks 1, 2, and 3. In the evaluation, no significant difference was found between the groups in terms of histological scores except for the first week (p=0.024, p=104, p=462, respectively). Conclusion: Although there was no statistically significant difference in the histological evaluation of both groups, except for the first week, the histological scores of Group 2, which underwent TTCP in all weeks, were higher. According to the results of this study, we believe that TTCP may be beneficial, particularly in the early stages of fracture healing.
dc.description.sponsorshipPerMed Health Products (Canakkale, Turkey)
dc.description.sponsorshipThis work was supported by PerMed Health Products (Canakkale, Turkey).
dc.identifier.doi10.52312/jdrs.2022.190
dc.identifier.endpage179
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue1
dc.identifier.pmid35361092
dc.identifier.scopus2-s2.0-85127425914
dc.identifier.scopusqualityQ2
dc.identifier.startpage172
dc.identifier.trdizinid522470
dc.identifier.urihttps://doi.org/10.52312/jdrs.2022.190
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/522470
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23098
dc.identifier.volume33
dc.identifier.wosWOS:000778960800020
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectFracture
dc.subjectfracture healing
dc.subjecttetracalcium phosphate
dc.titleTetracalcium phosphate treatment on experimental fracture model in rats
dc.typeArticle

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