Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases

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dc.contributor.authorKilinc, Nihal
dc.date.accessioned2025-01-27T21:21:19Z
dc.date.available2025-01-27T21:21:19Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: This study explores the correlation between the expression of E-cadherin, p53 tumor suppressor gene, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases. Patients and Methods: We have investigated tumor samples from sixty patients with invasive ductal breast carcinoma. 30 of the patients had axillary lymph node metastases and 30 had no axillary lymph node metastases. Tumor tissues of these patients were evaluated by immunohistochemistry for E-cadherin, p53, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR). Results: E-cadherin staining was not expressed in 39 patients (65%) with invasive ductal breast carcinoma. ER, PgR, p53, and c-erb-B2 signals were positive in 36 (60%), 26 (43.3%), 33 (55%), and 29 (48.3%) of the patients, respectively. PgR and c-erb-B2 expression was associated with lymph node metastases (p=0.009, p=0.001, respectively). No association was found between the reduced E-cadherin protein and age. The presence of E-cadherin was associated with axillary lymph node metastases and p53 (p<0.009, p<0.001, respectively). Conclusion: We found that, the p53 protein may play a role in regulation of E-cadherin protein expression in invasive ductal breast carcinomas with axillary lymph node metastases.
dc.identifier.doi10.5472/MMJoa.2802.07
dc.identifier.endpage104
dc.identifier.issn1309-9469
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84981711343
dc.identifier.scopusqualityQ4
dc.identifier.startpage99
dc.identifier.trdizinid186896
dc.identifier.urihttps://doi.org/10.5472/MMJoa.2802.07
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/186896
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28896
dc.identifier.volume28
dc.identifier.wosWOS:000439161700007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ, Fac Medicine
dc.relation.ispartofMarmara Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBreast carcinoma
dc.subjectE-cadherin
dc.subjectp53
dc.subjectc-erb-B2
dc.subjectER
dc.subjectPgR
dc.subjectMetastases
dc.titleRelation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases
dc.title.alternativeAksiller lenf nodu metastazlı invaziv duktal meme karsinomda E-cadherin, p53, c-erb-B2 (HER-2/neu) ve steroid reseptörleri (ER, PgR) ekspresyonu arasındaki ilişki
dc.typeArticle

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