Dental caries, oral hygiene and salivary characteristics in children with chronic kidney disease: a case-control study

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dc.authoridOktay, Sehkar/0000-0002-2878-288X
dc.contributor.authorDokumacigil, Nur Kodaman
dc.contributor.authorSezer, Berkant
dc.contributor.authorOktay, Sehkar
dc.contributor.authorAlpay, Harika
dc.contributor.authorKargul, Betul
dc.date.accessioned2025-05-29T02:58:07Z
dc.date.available2025-05-29T02:58:07Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground The aim of this study was to compare the oral health findings and salivary parameters of children with different stages of chronic kidney disease (CKD) with those of healthy peers. Methods Intraoral examinations were performed on 43 children aged 8-17 years with CKD and 40 healthy controls from the same pediatric nephrology clinic. Oral health was assessed using the DMFT/dft indices (decayed-missing-filled-teeth), debris index (DI), calculus index (CI), and simplified oral hygiene index (OHI-S). Saliva samples from the children were analyzed for salivary flow rate (SFR), pH, buffering capacity (BC), total oxidant status (TOS), total antioxidant capacity (TAOC), urea, creatinine (Cr), calcium (Ca), potassium (K), phosphorus (P), and salivary alpha-amylase (SAA). Spearman's rho coefficient was used to examine the relationship between salivary and serum biomarkers levels and oral health findings.ResultsWhile the DMFT/dft scores were lower in children with CKD (p = 0.001), DI, CI, and OHI-S scores were higher in healthy peers (p < 0.001). Children with CKD had lower SFR, Ca, and TAOC levels, and higher BC, pH, urea, Cr, K, P, TOS, and SAA levels (p < 0.001) compared to healthy controls. Later stages of CKD was associated with the lower dft ( rs= - 0.35; p = 0.022). ConclusionsChildren with CKD exhibit fewer caries and poorer oral hygiene compared to their healthy peers, and their saliva characteristics differ significantly from those of the healthy group. Disease-related changes in serum and salivary character-istics affect the oral health of children with CKD, necessitating collaboration between pediatric nephrologists and dentists.Trial registrationClinicalTrials.gov (NCT06578832).
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK); Marmara University Scientific Research Committee (BAPKO) [TDK-2023-10958]
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK). This research was funded by a research grant from the Marmara University Scientific Research Committee (BAPKO), with project number TDK-2023-10958. This article is based on the doctoral thesis titled Assessment of the Oral Health Status of Children with Chronic Kidney Disease, conducted at the Institute of Health Sciences, Marmara University.
dc.identifier.doi10.1007/s00467-025-06730-4
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.pmid40105933
dc.identifier.scopus2-s2.0-105000555103
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00467-025-06730-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30284
dc.identifier.wosWOS:001449397700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPediatric Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectBiomarkers
dc.subjectChildren
dc.subjectChronic kidney disease
dc.subjectDental caries
dc.subjectOral hygiene
dc.subjectSaliva
dc.titleDental caries, oral hygiene and salivary characteristics in children with chronic kidney disease: a case-control study
dc.typeArticle

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