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Öğe Six-year survival and clinical performance of glass hybrid restorations following selective caries removal in teeth with molar incisor hypomineralization: a prospective cohort study(Springer Heidelberg, 2025) Sezer, Berkant; Şen Yavuz, Betül; İşseven, Ceyda İpek; Tuğcu, Nihan; Çalışkan, Cansu; Durmuş, Başak; Kargül, BetülObjectives This study aimed to evaluate the clinical success and long-term survival of glass hybrid restorations in permanent first molars affected by molar incisor hypomineralization (MIH) following selective caries removal (SCR) over a six-year follow-up period. Materials and methods This prospective cohort study included a total of 134 MIH-affected molars in 58 children (mean age 8.94 +/- 1.41 years) restored with glass hybrid materials after SCR. Clinical outcomes were assessed at baseline and at 6, 12, 18, 24, and 72 months using modified USPHS criteria. Kaplan-Meier survival analysis and Cox proportional hazards regression with robust standard errors were conducted to evaluate restoration survival and identify potential predictors. Results The overall estimated mean survival time of restorations was 59.82 +/- 1.50 months. The survival probabilities for mild and severe lesions at six-year were 24.3% and 11.1%, respectively. Multivariate Cox proportional hazards regression with robust standard errors indicated that lesion severity, medium lesion extension, and large lesion extension had a statistically significant impact on restoration survival (p < 0.001 for all). While survival was satisfactory up to 2-3 years, a marked decline was observed over time, particularly in severely affected molars. Conclusions Glass hybrid restorations demonstrated acceptable clinical performance in MIH-affected molars in the short to medium term but showed significant limitations in long-term survival.Öğe Dental caries, oral hygiene and salivary characteristics in children with chronic kidney disease: a case-control study(Springer, 2025) Kodaman Dokumacıgil, Nur; Sezer, Berkant; Oktay, Sehkar; Alpay, Harika; Kargül, BetülBackground The aim of this study was to compare the oral health findings and salivary parameters of children with different stages of chronic kidney disease (CKD) with those of healthy peers. Methods Intraoral examinations were performed on 43 children aged 8-17 years with CKD and 40 healthy controls from the same pediatric nephrology clinic. Oral health was assessed using the DMFT/dft indices (decayed-missing-filled-teeth), debris index (DI), calculus index (CI), and simplified oral hygiene index (OHI-S). Saliva samples from the children were analyzed for salivary flow rate (SFR), pH, buffering capacity (BC), total oxidant status (TOS), total antioxidant capacity (TAOC), urea, creatinine (Cr), calcium (Ca), potassium (K), phosphorus (P), and salivary alpha-amylase (SAA). Spearman's rho coefficient was used to examine the relationship between salivary and serum biomarkers levels and oral health findings.ResultsWhile the DMFT/dft scores were lower in children with CKD (p = 0.001), DI, CI, and OHI-S scores were higher in healthy peers (p < 0.001). Children with CKD had lower SFR, Ca, and TAOC levels, and higher BC, pH, urea, Cr, K, P, TOS, and SAA levels (p < 0.001) compared to healthy controls. Later stages of CKD was associated with the lower dft ( rs= - 0.35; p = 0.022). ConclusionsChildren with CKD exhibit fewer caries and poorer oral hygiene compared to their healthy peers, and their saliva characteristics differ significantly from those of the healthy group. Disease-related changes in serum and salivary character-istics affect the oral health of children with CKD, necessitating collaboration between pediatric nephrologists and dentists.Trial registrationClinicalTrials.gov (NCT06578832).Öğe Evaluation of the effect of dental caries, oral hygiene, and treatment need on oral health-related quality of life among Turkish orphan children and adolescents(Bmc, 2025) Akbeyaz Sivet, Ecem; Sezer, Berkant; Atmaca, Neslihan; Huseynova, Narmin; Kargül, BetülBackground The oral and dental health and related quality of life of orphan children and adolescents-who are considered a vulnerable population-are critical for both individual and public health. Objectives This study aimed to investigate the status of the dental caries, oral hygiene, and dental treatment needs among a group of Turkish male orphan children and adolescents, as well as their impact on oral health-related quality of life. Methods A total of 112 orphan children and adolescents aged between 9 and 17 years living in a residential care facility in Istanbul, T & uuml;rkiye, were involved in this cross-sectional study. A comprehensive examination was conducted on each individual, encompassing the assessment of dental caries using the decayed, missing, and filled teeth (DMFT/dft) index, oral hygiene using the debris (DI-S), calculus (CI-S), and simplified oral hygiene (OHI-S) indices, and dental treatment need using the treatment need index (TNI). Oral health-related quality of life was evaluated using the validated Turkish version of the Child Oral Health Impact Profile-Short Form (COHIP-SF-19). The relationship between oral health-related quality of life and explanatory variables was evaluated using a multivariable linear regression model. Results The mean age of the participants was 12 +/- 1.79 years. The mean DMFT score was 4.57 +/- 3.42, and the mean OHI-S score was 1.4 +/- 0.52. Participants had a mean COHIP-SF-19 score of 57.79 +/- 14.11, with 25% requiring at least one tooth to undergo radical treatment. Multivariable linear regression analysis indicated that the DMFT score (p = 0.009) and the need for radical treatment (TNI code 6) (p < 0.001) had a statistically significant impact on oral health-related quality of life among orphan children and adolescents aged 13-17. Conclusions This study underscores that dental caries and the need for radical treatment significantly impact the oral health-related quality of life of orphan children and adolescents.Öğe Nine-year Follow-up of Autotransplantation in the Maxillary Anterior Region: Replacing a Fused Incisor with a Supernumerary Tooth(Elsevier Inc., 2025) Sezer, Berkant; Şen Yavuz, Betül; Korkut, Bora; Menteş, AliThe goal of tooth autotransplantation is to restore a missing tooth by using a functional tooth from the same patient. Although this procedure is gaining more recognition as a viable treatment option in dentistry, it is important to monitor and report long-term results. This case report presents the long-term follow-up of a fused maxillary central incisor that was extracted and replaced with a supernumerary tooth. Although the donor tooth displayed favorable characteristics, including an intact periodontal ligament and minimal extraoral time, which contributed to the success of the transplantation, it also presented certain disadvantages, such as having a fully developed root apex. Over a 9-year follow-up period, no clinical symptoms indicative of functional failure were observed. However, external cervical root resorption, first detected at the 6-year follow-up, progressed by the ninth year. Despite the lack of clinical symptoms, radiographic findings suggested that the root resorption was a significant concern. This case underscores the potential for long-term success of autotransplanted teeth, even in complex scenarios involving fused teeth. However, it also highlights the importance of thorough, long-term monitoring to detect complications such as root resorption. The findings suggest that, while autotransplantation can offer favorable outcomes, careful management and periodic evaluations are essential to ensure the longevity of the transplanted tooth. © 2025 American Association of EndodontistsÖğe Dental age and tooth development in children with molar-incisor hypomineralization: A case-control study(Elsevier Ltd, 2022) Sezer, Berkant; Çarıkçıoğlu, Burak; Kargül, BetülObjective: The aim of the study was to determine the dental age for the evaluation of tooth development in children with molar-incisor hypomineralization (MIH) by using the Willems method, Cameriere-European formula, and London Atlas. Design: Panoramic radiographs of 308 children between the ages of 6–13 diagnosed with MIH and the same number of sex- and age-matched children without MIH were evaluated by two different examiners using the Willems method, Cameriere-European formula, and London Atlas. The mean difference between chronological age and dental age in both groups was calculated for each sex and age. The mean absolute error was used to determine the accuracies of the Willems method, Cameriere-European formula, and London Atlas. Results: There was a statistically significant difference found only in Willems method in dental age estimation between the groups with and without MIH (P = 0.001). In the evaluation performed with Cameriere-European formula and London Atlas, which are more accurate methods for dental age estimation in both groups, no statistically significant difference was found in dental age estimation between the two groups (P = 0.322, P = 0.290, respectively). There was a statistically significant intense linear correlation for three methods in both groups (P < 0.001). Conclusions: MIH, which is a developmental enamel defect, does not affect dental age and tooth development since there was no significant difference between groups with and without MIH according to the evaluations made with accurate dental age estimation methods.Öğe Prevention and management of dental erosion and decay(BMC, 2024) Campus, Guglielmo; Niu, John Yun; Sezer, Berkant; Yu, Ollie YiruThe 2017 Global Disease Study revealed 2.3 billion untreated cavities and 139 million other oral conditions like dental erosion. Modern treatments prioritise controlling etiological factors and preventing related diseases. This Editorial invites researchers to contribute to the collection, 'Prevention and management of dental erosion and decay'.Öğe In-vivo evaluation of the effects of short-term dehydration and rehydration on the color differences of immature permanent incisor teeth(Wiley, 2024) Buldur, Mehmet; Misilli, Tuğba; Sezer, BerkantObjective: It is aimed to evaluate the color changes of upper central incisor teeth with different root maturation levels after 15 min of dehydration and rehydration. Materials and Methods: Using the Cvek classification, 60 participants were divided into five groups. A spectrophotometer, equipped with a specially designed jig, was utilized for color measurements. Following isolation, color measurements were conducted at the dehydration process intervals of baseline, 1st, 2nd, 3rd, 5th, 7th, 10th, and 15th minutes. After mouth rinsing, measurements were repeated at the same time intervals during the rehydration process. CIEDE2000 (Delta E-00) values and the Whiteness Index (WID) were obtained to compare the color changes between the initial readings and each interval. Friedman and Repeated Measures ANOVA were applied to compare classes by time during the dehydration and rehydration periods, as well as ANOVA and Kruskal-Wallis tests to compare by classes for each time (p < 0.05). Results: Significant differences emerged in the mean Delta E-00 values during dehydration and rehydration periods across all Cvek Classes (p < 0.05). While no statistically significant differences were observed among Classes at different minutes during the rehydration period (p > 0.05), it was particularly noted that the mean Delta E-00 values of Classes 2, 3, and 5 at the 2nd minute of dehydration were statistically significantly higher than the mean of Class 1 (p < 0.05). However, when evaluating the starting and ending measurements of both dehydration and rehydration processes, and the overall change in Delta E-00 and Delta WID, no significant variations were detected across the Classes (p > 0.05). Conclusions: In teeth that have just erupted and are still undergoing root development, dehydration in the initial minutes results in noticeable color changes. However, the change in Delta E-00 and Delta WID of the teeth was found to be similar after the dehydration and rehydration processes.Öğe Assessing one-shade composite resin color stability in response to everyday drinks(BMC, 2024) Düzyol, Mustafa; Düzyol, Esra; Çarıkcıoğlu, BurakObjective The aim of our study was to measure the color changes in one-shade composite resins when exposed to common drinks, such as tea, cola and coffee. Materials/Methods In our study, Omnichroma, Vitrra APS Unique, GC A'chord and Charisma Diamond One composite resins were used. Composite resins were placed in stainless steel molds with depths of 2 mm and diameters of 5 mm. Ten specimens were immersed in tea, 10 specimens were immersed in coffee, 10 specimens were immersed in cola and 10 specimens were immersed in distilled water in an incubator at 37 degrees C for 14 days. Color measurements were performed at the beginning of the study and after 24 h and 14 days. Color values were measured using a CIE L*a*b* system with a spectrophotometer device. Color and translucency changes were calculated and data analyzed using one-way ANOVA, two-way ANOVA, and post-hoc Tukey test (p < 0.05). Results The greatest color changes occurred in the tea and coffee groups; the smallest color change occurred in the control group. After 14 days, the greatest color change was observed in the Charisma + Coffee group; the smallest color change was observed in the Omnichroma + Water group. The transparency and contrast ratios changed in all groups, and the smallest change occurred in the Omnichroma control group. Conclusion Significant differences were found in the composite color changes after immersion in beverages. The color variations significantly differed depending on the beverage in which the specimens were immersed. The initial contrast ratio was markedly different from the examined materials. Clinical significance The study emphasizes the significance of common beverages on the color stability of one-shade composite resins, underlining the need of appropriate material selection for long-term aesthetic effects in one-shade composite resin restorations.Öğe Evaluating the accuracy of Chat Generative Pre-trained Transformer version 4 (ChatGPT-4) responses to United States Food and Drug Administration (FDA) frequently asked questions about dental amalgam(BMC, 2024) Buldur, Mehmet; Sezer, BerkantBackground The use of artificial intelligence in the field of health sciences is becoming widespread. It is known that patients benefit from artificial intelligence applications on various health issues, especially after the pandemic period. One of the most important issues in this regard is the accuracy of the information provided by artificial intelligence applications.Objective The purpose of this study was to the frequently asked questions about dental amalgam, as determined by the United States Food and Drug Administration (FDA), which is one of these information resources, to Chat Generative Pre-trained Transformer version 4 (ChatGPT-4) and to compare the content of the answers given by the application with the answers of the FDA.Methods The questions were directed to ChatGPT-4 on May 8th and May 16th, 2023, and the responses were recorded and compared at the word and meaning levels using ChatGPT. The answers from the FDA webpage were also recorded. The responses were compared for content similarity in Main Idea, Quality Analysis, Common Ideas, and Inconsistent Ideas between ChatGPT-4's responses and FDA's responses.Results ChatGPT-4 provided similar responses at one-week intervals. In comparison with FDA guidance, it provided answers with similar information content to frequently asked questions. However, although there were some similarities in the general aspects of the recommendation regarding amalgam removal in the question, the two texts are not the same, and they offered different perspectives on the replacement of fillings.Conclusions The findings of this study indicate that ChatGPT-4, an artificial intelligence based application, encompasses current and accurate information regarding dental amalgam and its removal, providing it to individuals seeking access to such information. Nevertheless, we believe that numerous studies are required to assess the validity and reliability of ChatGPT-4 across diverse subjects.Öğe Treatment Strategies for Incisors of Children Affected by Molar Incisor Hypomineralization: A Narrative Review(Mdpi, 2024) Sezer, Berkant; Çarıkcıoğlu, BurakToday, molar incisor hypomineralization (MIH), which affects approximately one in seven children, is defined as a hypomineralized developmental enamel defect that often impacts at least one permanent first molar and frequently affects permanent incisors as well. Symptoms and signs include demarcated opacities of various colors, post-eruptive enamel deterioration, atypical caries and restorations, hypersensitivity, tooth loss due to MIH, and difficulty in achieving anesthesia. A detailed review of the scientific literature shows that there are many studies evaluating different treatment approaches for permanent first molars affected by MIH. On the other hand, there are very few scientific studies evaluating treatment approaches for affected incisors in patients with MIH. Most of these studies consist of case reports or series. White/creamy and/or yellow/brown demarcated opacities are commonly observed in affected incisors in patients with MIH. While these opacities increase the susceptibility of enamel to deterioration and dental caries, they also cause aesthetic problems and related psychosocial consequences. Treatment methods, such as resin infiltration, microabrasion, and/or dental bleaching, have been proposed for aesthetic and restorative purposes in affected incisors in patients with MIH. Additionally, various approaches to increase mineral content and relieve hypersensitivity have been recommended. The number of randomized controlled and prospective studies is quite low, but many case reports and case series have been encountered. The purpose of this review was to provide a comprehensive overview of the different treatment management modalities for permanent incisors affected by MIH. As a result, while resin infiltration, dental bleaching, microabrasion, and/or etch-bleach-seal techniques are preferred for aesthetic and restorative purposes in these teeth, it has been observed that agents containing casein phosphopeptide amorphous calcium phosphate, casein phosphopeptide amorphous calcium fluoride phosphate, fluoride, and calcium glycerophosphate increase the mineral content. Additionally, studies have reported that ozone and low-level laser therapy, in addition to these remineralizing agents, reduce hypersensitivity in these teeth. Although the findings of this review indicate that the level of evidence for current approaches is not high, clinicians may prefer one or more of the treatment approaches mentioned in this article based on experience and patient expectations.Öğe Comparative evaluation of the remaining dentin volume following instrumentation with rotary, reciprocating, and hand files during root canal treatment in primary molars: An ex vivo study(Elsevier Taiwan, 2024) Eren, İrem; Sezer, BerkantBackground/purpose: The effectiveness of root canal treatments with different file systems in primary teeth is important in terms of clinical practice and the use of file systems that work with different principles in primary tooth pulpectomy is becoming widespread. The amount of remaining dentin in the coronal region of the root is important in terms of the prognosis of the tooth and the long-term success of the treatment in teeth that have undergone root canal treatment. The aim of this study was to evaluate the remaining dentin volume in the coronal part of the root after the use of rotary, reciprocating, and conventional hand files in primary tooth pulpectomy. Materials and methods: A total of 30 primary molars were divided into three groups. In each group, the preparations were made with three different file types: WaveOne Gold, which works with reciprocating motion; TruNatomy, which works with rotational motion; and conventional hand files. The three-dimensional images were evaluated for remaining dentin volume in the 2-mm coronal part of the root. Group means were compared using one-way analysis of variance, and post hoc analyses were performed with the Tukey test. Results: There was no statistically significant difference between the groups in terms of preoperative and postoperative dentin volume (P > 0.05). The mean difference after preparation was observed the most in the WaveOne Gold group and the least in the TruNatomy group. When the mean percentage differences were evaluated, it was observed that statistically significantly more dentin volume was preserved after the preparation with TruNatomy than with WaveOne Gold (P = 0.021). Conclusion: In primary tooth pulpectomy, file systems working with rotational motion can be preferred over file systems working with reciprocating motion in preserving the amount of dentin in the 2-mm coronal part of the root.Öğe The influence of sociodemographic and health-related factors, clinical education status, and sleep quality on work-related quality of life among dental students(Wiley, 2024) Sezer, Berkant; Sıddıkoğlu, Duygu; Doğan, İlkay; Taşdemir, Mehmet Can; Ateş, GizemIntroduction: With the premise that the demanding educational process and associated factors could influence the work-related quality of life (WRQoL) of dental students, this study aimed to investigate the influence of diverse sociodemographic and health-related factors, clinical education status, and sleep quality on the WRQoL of dental students. Materials and Methods: A three-part questionnaire was administered to a group of preclinical and clinical dental students studying in different classes. The first part of the questionnaire included various sociodemographic and health-related questions. In the second part, the multidimensional 23-item WRQoL scale, with established validity and reliability, was applied to evaluate the WRQoL of the students. The last part of the questionnaire included the Pittsburgh Sleep Quality Index, comprising 19 items. General linear models were created to predict subscale scores using sociodemographic and health-related characteristics, as well as univariate significant independent variables. Results: It was observed that the majority of the participants (78.2%) had poor sleep quality. Being clinical dental students had a significant and positive effect on the stress at work domain of WRQoL (p = .006), while it had a significant and negative effect on the home-work interface domain (p < .001). The decrease in sleep quality had a significant and negative effect on all domains of WRQoL (p < .05) except for the stress at work domain. Conclusions: Clinical education status, regular smoking, and sleep quality significantly affect different domains of dental students' WRQoL. Changes in these factors should be considered in approaches to increasing students' WRQoL.Öğe Evaluation of the differences in the localization of the lingula mandibulae according to pubertal development in children: A new anthropological and forensic approach(Elsevier Ltd, 2024) Eren, Hakan; Sezer, Berkant; Deniz, YeşimObjective: This study aims to investigate changes in lingula mandibulae localization before and after puberty and sex differences. Design: 288 panoramic radiographs evaluated retrospectively were divided into four groups according to pubertal development: under and over 10 years old for females and under and over 11 years old for males. Four anatomic sites were used as reference points: (a) the anterior border of the ramus; (b) the posterior border of the ramus; (c) the deepest point of mandibular notch; and (d) the angulus mandibulae. The ratio of the distances from the lingula mandibulae to points (a) and (b) and the ratio of the distances from the lingula mandibulae to points (c) and (d) were determined. Two-way ANOVA was performed to assess differences between subgroups based on sex and puberty, and a Bonferroni post-hoc test was performed for multiple comparisons. Results: Puberty and sex has a significant interaction effect on the vertical location of the lingula mandibulae. Postpubertal lingula mandibulae is positioned proportionally more anteriorly by prepubertal localization. In addition, the lingula mandibulae is situated more posteriorly in females compared to males. A significant interaction effect of puberty and sex was observed in relation to the vertical positioning of the lingula mandibulae. Conclusions: The spatial localization of the lingula mandibulae and its spatial displacement with age can be used both in estimating sex and the onset of puberty. Changes in the localization of lingula mandibulae according to pubertal development and sex can be used in forensic and anthropological contexts.Öğe Comparison of the Effects of WaveOne Gold, TruNatomy, and Conventional Hand Files on Remaining Dentin Volume in the Coronal Part of the Root and Preparation Efficiency in Mandibular Molars(Elsevier Inc., 2023) Eren, İrem; Sezer, BerkantIntroduction: The use of file systems that work with different principles in root canal treatment is becoming widespread. The aim of this study was to evaluate the remaining dentine volume in the coronal region of the root and preparation efficiency after the use of conventional hand files, WaveOne Gold; which works with reciprocating motion, and TruNatomy; which works with rotational motion in the root canal treatment of mandibular molar teeth. Methods: All canals of permanent mandibular molars (n = 36) were used. Root canals in each group (n = 12) were prepared with conventional hand files, WaveOne Gold, and TruNatomy. The three-dimensional images were evaluated for remaining dentine volume in the coronal two-millimeter region of the root and change in volume of the entire root canal space. Results: There was no statistically significant difference between the groups in terms of mean differences pre and postpreparation (P > .05). The mean differences after preparation were observed the most in the WaveOne Gold group and the least in the TruNatomy group in the coronal two-millimeter region of the root and entire canal volume, but the differences were not significant (P > .05, P > .05, respectively). Conclusions: Conventional hand files, WaveOne Gold working with reciprocating motion, and TruNatomy working with rotational motion, which are the file systems used in the study, are not superior to each other in terms of remaining dentin volume in the coronal two-millimeter region of the root and preparation efficiency in the entire root canal space in mandibular molars.Öğe Does the scientific literature provide sufficient information on incisors affected by molar incisor hypomineralisation?(Springer Science and Business Media Deutschland GmbH, 2023) Sezer, BerkantMolar incisor hypomineralisation (MIH), which was defined for the first time by Weerheijm et al. (2001) twenty-one years ago as a qualitative, hypomineralised enamel defect in which at least one permanent first molar is affected and the condition is frequently observed in permanent incisors, remains an important health problem.Öğe Assessment of the oral health status of children with chronic kidney disease(Springer Science and Business Media Deutschland GmbH, 2023) Sezer, Berkant; Kaya, Remziye; Kodaman Dokumacıgil, Nur; Sıddıkoğlu, Duygu; Güven, Serçin; Yıldız, Nurdan; Alpay, Harika; Kargül, BetülBackground There are various oral symptoms related to the disease and its management in individuals with chronic kidney disease (CKD). The aim of the study was to investigate the oral health status of children with different stages of CKD, kidney transplant recipients (KTR), and healthy children. Methods A total of seventy-one children diagnosed with CKD and fifty-two healthy children were included in the study. Each patient was examined for dental caries by the decayed-missing-filled-teeth (DMFT/dmft) index and the International Caries Detection and Assessment System (ICDAS-II), developmental defects of enamel (DDE) by the DDE index, and oral hygiene by the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indices. Results The median number of DMFT/dmft was 1.00 (interquartile range (IQR):1.00-4.00) in children with stage 1-3 CKD, 0.00 (IQR: 0.00-2.50) in stage 4-5 children, 0.00 (IQR: 1.00-3.00) in KTR, and 8.00 (IQR: 1.00-13.00) in healthy children. According to ICDAS-II categories, the percentage of children with severe caries was 53.8% in healthy children, while it was 44.4% in KTR, 25.9% in stage 1-3, and 11.4% in stage 4-5 children. While the percentage of children with DDE was 88.8% in KTR, 80% in stage 4-5, and 66.7% in stage 1-3 children, this rate was 44.2% in healthy children. The highest mean OHI-S score was observed in stage 4-5 children (2.10 +/- 1.08), followed by KTR (1.46 +/- 1.19), stage 1-3 (1.27 +/- 0.61), and healthy children (0.45 +/- 0.44), respectively. Conclusions Compared to healthy children, children with CKD had more debris accumulation, calculus formation, and more DDE but a lower severity of dental caries.Öğe Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study(Springer Science and Business Media Deutschland GmbH, 2023) Sezer, Berkant; Kodaman Dokumacıgil, Nur; Kaya, Remziye; Güven, Serçin; Türkkan, Özde Nisa; Çiçek, Neslihan; Alpay, Harika; Kargül, BetülObjectives: The aim of this study was to investigate the association between serum biomarkers and oral health parameters in children with chronic kidney disease (CKD). Materials and methods: Serum hemoglobin, blood urea nitrogen, serum creatinine, calcium, parathormone, magnesium, and phosphorus levels were measured in 62 children with CKD aged between 4 and 17 years. Intraoral examinations of the patients were performed by two different pediatric dentists. Dental caries was assessed using the decayed-missing-filled-teeth (DMFT/dmft) indexes, and oral hygiene was assessed using the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indexes. Spearman’s rho coefficient and generalized linear modeling were used to examine the association between serum biomarkers and oral health parameters. Results: The results of the study showed that there were negative and statistically significant correlations between serum hemoglobin and creatinine levels and dmft scores in pediatric patients with CKD (p = 0.021 and p = 0.019, respectively). Furthermore, blood urea nitrogen levels and DI and OHI-S scores (p = 0.047 and p = 0.050, respectively); serum creatinine levels and DI, CI, and OHI-S scores (p = 0.005, p = 0.047, p = 0.043, respectively); and parathormone levels and CI and OHI-S scores (p = 0.001 and p = 0.017, respectively) were found to be positively and statistically significantly related. Conclusions: There are associations between various serum biomarker levels and dental caries and oral hygiene parameters in pediatric patients with CKD. Clinical relevance: The impact of changes in serum biomarkers on oral and dental health is important for dentists’ and medical professionals' approaches to patients' oral and systemic health.Öğe Effects of radiotherapeutic X-ray irradiation on cervical enamel(Taylor and Francis Ltd., 2021) Deniz, Yeşim; Aktaş, Çağatay; Misilli, Tuğba; Çarıkçıoğlu, BurakPurpose Therapeutic radiation used for head and neck cancers mainly affects the cervical region of the tooth. To better understand the impact of therapeutic radiation on tooth, we aimed to examine the crystallinity, micro-morphology, and elemental composition of the cervical inner enamel located adjacent to the dento-enamel junction. Materials and methods Ninety-one specimens obtained from 16 impacted third mandibular molars were randomly divided into seven groups (0, 10, 20, 30, 40, 50, and 60 Gy irradiation groups). Energy-dispersive X-ray spectroscopy (EDX) and scanning electron microscopy (SEM) were performed after the irradiation by 6 MV photon energy. The X-ray diffraction (XRD) were conducted in every group before and after irradiation. Elemental compositions, and Ca/P, P/N, Ca/N atomic ratios were subjected to the Shapiro-Wilk normality test. All of the elements except Mg showed a normal distribution and were compared by the one-way ANOVA. The non-normally distributed Mg data and Ca/P, P/N, and Ca/N ratios were compared by the Kruskal-Wallis test. Results The results showed that widening in the interprismatic spaces were observed in the experimental groups subjected to 30 Gy and the following increased doses. In addition, there were no significant differences in C, O, Ca, P, N percentages between irradiated and non-irradiated groups (p > .05). An increase in atomic ratio of the Mg was detected after samples conducted by 60 Gy radiation dose (p < .05). The stoichiometric Ca/P, Ca/N, and P/N atomic ratios did not change by irradiation (p > .05). The XRD peaks of the inner enamel crystalline phase showed a slight decline in the 60 Gy radiation dose group. Conclusion Radiation effects begin to be seen after 30 Gy radiation dose groups. The widen interprismatic spaces seen obviously in 50 Gy and 60 Gy dose groups. Besides Mg ratio showed an increase in the 60 Gy dose group. But it should be thought that radiation caries is a multi-factorial disease that is in collaboration with various radiation-induced side effects.Öğe Accuracy of the radiographic methods of Willems, Cameriere and Blenkin-Evans on age estimation for Turkish children in the northwest Anatolia region(Taylor and Francis Ltd., 2021) Çarıkçıoğlu, Burak; Değirmenci, AlpinThe aim of this study is to compare the accuracy of the Willems Method (WM), Cameriere Method (CM) and Blenkin-Evans Method (BM) in the same study sample and determine which one is more suitable for Turkish population. This study included panoramic radiographs of 1024 individuals (619 boys and 585 girls) aged between 6.00 and 15.99 years. Dental age (DA) was calculated using WM, CM and BM for the total study sample, and separately, taking into account age groups and gender. Repeatability statistics evaluated with Cohen's Kappa test. The differences between chronological age (CA) and the DA were statistically tested using a paired sample t-test and the Wilcoxon signed-rank test. WM overestimated the CA by 0.23 years, while both CM and BM underestimated it by 0.51 and 0.05 years, respectively. In all samples, the DA-CA difference was significant in all methods with one exception BM in boys. Although WM and BM both seem satisfactory in age estimation for children at the northwest Anatolia region of Turkey, BM performs slightly better than CM and it has shown the most accurate results except for the 15 year age group.Öğe Accuracy of the London Atlas, Haavikko's Method and Cameriere's European Formula of dental age estimation in Turkish children(Elsevier B.V., 2022) Sezer, Berkant; Çarıkcıoğlu, BurakAge estimation is a mandatory procedure when the chronological age is unknown or uncertain. Dental development is the preferred characteristic for estimating a child's age. There are many methods for dental age estimation, but their reliability can differ between populations. This study compared the accuracy of three of these methods—the London Atlas (LA), Haavikko's method (HM), and Cameriere's European formula (CF)—in Turkish children living in northwestern Turkey. Panoramic radiographs of 980 children from northwestern Turkey aged between 6.00 and 14.99 years were examined for the whole study group and separately for different ages and sexes by all three methods. Statistical differences between chronological age and dental age were tested using the paired sample t-test and the Wilcoxon signed-rank test. The LA, HM, and CF accuracies were determined based on the mean absolute error. Spearman's rank correlation coefficient showed that the correlation between chronological age and dental age for both sexes was linear for all methods. The LA overestimated the chronological age by 0.09 years, while HM and CF underestimated it by 0.49 and 0.11 years, respectively. The difference between dental age and chronological age was significant in all samples, for all methods, except for the LA in boys. When boys, girls, and the total sample were evaluated, values with the lowest mean absolute error were obtained by HM and were statistically significant in all three groups. Therefore, HM is more accurate than the LA and CF for dental age estimation in Turkish children living in northwestern Turkey.
