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Öğe Six-year survival and clinical performance of glass hybrid restorations following selective caries removal in teeth with molar incisor hypomineralization: a prospective cohort study(Springer Heidelberg, 2025) Sezer, Berkant; Şen Yavuz, Betül; İşseven, Ceyda İpek; Tuğcu, Nihan; Çalışkan, Cansu; Durmuş, Başak; Kargül, BetülObjectives This study aimed to evaluate the clinical success and long-term survival of glass hybrid restorations in permanent first molars affected by molar incisor hypomineralization (MIH) following selective caries removal (SCR) over a six-year follow-up period. Materials and methods This prospective cohort study included a total of 134 MIH-affected molars in 58 children (mean age 8.94 +/- 1.41 years) restored with glass hybrid materials after SCR. Clinical outcomes were assessed at baseline and at 6, 12, 18, 24, and 72 months using modified USPHS criteria. Kaplan-Meier survival analysis and Cox proportional hazards regression with robust standard errors were conducted to evaluate restoration survival and identify potential predictors. Results The overall estimated mean survival time of restorations was 59.82 +/- 1.50 months. The survival probabilities for mild and severe lesions at six-year were 24.3% and 11.1%, respectively. Multivariate Cox proportional hazards regression with robust standard errors indicated that lesion severity, medium lesion extension, and large lesion extension had a statistically significant impact on restoration survival (p < 0.001 for all). While survival was satisfactory up to 2-3 years, a marked decline was observed over time, particularly in severely affected molars. Conclusions Glass hybrid restorations demonstrated acceptable clinical performance in MIH-affected molars in the short to medium term but showed significant limitations in long-term survival.Öğe Dental caries, oral hygiene and salivary characteristics in children with chronic kidney disease: a case-control study(Springer, 2025) Kodaman Dokumacıgil, Nur; Sezer, Berkant; Oktay, Sehkar; Alpay, Harika; Kargül, BetülBackground The aim of this study was to compare the oral health findings and salivary parameters of children with different stages of chronic kidney disease (CKD) with those of healthy peers. Methods Intraoral examinations were performed on 43 children aged 8-17 years with CKD and 40 healthy controls from the same pediatric nephrology clinic. Oral health was assessed using the DMFT/dft indices (decayed-missing-filled-teeth), debris index (DI), calculus index (CI), and simplified oral hygiene index (OHI-S). Saliva samples from the children were analyzed for salivary flow rate (SFR), pH, buffering capacity (BC), total oxidant status (TOS), total antioxidant capacity (TAOC), urea, creatinine (Cr), calcium (Ca), potassium (K), phosphorus (P), and salivary alpha-amylase (SAA). Spearman's rho coefficient was used to examine the relationship between salivary and serum biomarkers levels and oral health findings.ResultsWhile the DMFT/dft scores were lower in children with CKD (p = 0.001), DI, CI, and OHI-S scores were higher in healthy peers (p < 0.001). Children with CKD had lower SFR, Ca, and TAOC levels, and higher BC, pH, urea, Cr, K, P, TOS, and SAA levels (p < 0.001) compared to healthy controls. Later stages of CKD was associated with the lower dft ( rs= - 0.35; p = 0.022). ConclusionsChildren with CKD exhibit fewer caries and poorer oral hygiene compared to their healthy peers, and their saliva characteristics differ significantly from those of the healthy group. Disease-related changes in serum and salivary character-istics affect the oral health of children with CKD, necessitating collaboration between pediatric nephrologists and dentists.Trial registrationClinicalTrials.gov (NCT06578832).Öğe Evaluation of the effect of dental caries, oral hygiene, and treatment need on oral health-related quality of life among Turkish orphan children and adolescents(Bmc, 2025) Akbeyaz Sivet, Ecem; Sezer, Berkant; Atmaca, Neslihan; Huseynova, Narmin; Kargül, BetülBackground The oral and dental health and related quality of life of orphan children and adolescents-who are considered a vulnerable population-are critical for both individual and public health. Objectives This study aimed to investigate the status of the dental caries, oral hygiene, and dental treatment needs among a group of Turkish male orphan children and adolescents, as well as their impact on oral health-related quality of life. Methods A total of 112 orphan children and adolescents aged between 9 and 17 years living in a residential care facility in Istanbul, T & uuml;rkiye, were involved in this cross-sectional study. A comprehensive examination was conducted on each individual, encompassing the assessment of dental caries using the decayed, missing, and filled teeth (DMFT/dft) index, oral hygiene using the debris (DI-S), calculus (CI-S), and simplified oral hygiene (OHI-S) indices, and dental treatment need using the treatment need index (TNI). Oral health-related quality of life was evaluated using the validated Turkish version of the Child Oral Health Impact Profile-Short Form (COHIP-SF-19). The relationship between oral health-related quality of life and explanatory variables was evaluated using a multivariable linear regression model. Results The mean age of the participants was 12 +/- 1.79 years. The mean DMFT score was 4.57 +/- 3.42, and the mean OHI-S score was 1.4 +/- 0.52. Participants had a mean COHIP-SF-19 score of 57.79 +/- 14.11, with 25% requiring at least one tooth to undergo radical treatment. Multivariable linear regression analysis indicated that the DMFT score (p = 0.009) and the need for radical treatment (TNI code 6) (p < 0.001) had a statistically significant impact on oral health-related quality of life among orphan children and adolescents aged 13-17. Conclusions This study underscores that dental caries and the need for radical treatment significantly impact the oral health-related quality of life of orphan children and adolescents.Öğe Nine-year Follow-up of Autotransplantation in the Maxillary Anterior Region: Replacing a Fused Incisor with a Supernumerary Tooth(Elsevier Inc., 2025) Sezer, Berkant; Şen Yavuz, Betül; Korkut, Bora; Menteş, AliThe goal of tooth autotransplantation is to restore a missing tooth by using a functional tooth from the same patient. Although this procedure is gaining more recognition as a viable treatment option in dentistry, it is important to monitor and report long-term results. This case report presents the long-term follow-up of a fused maxillary central incisor that was extracted and replaced with a supernumerary tooth. Although the donor tooth displayed favorable characteristics, including an intact periodontal ligament and minimal extraoral time, which contributed to the success of the transplantation, it also presented certain disadvantages, such as having a fully developed root apex. Over a 9-year follow-up period, no clinical symptoms indicative of functional failure were observed. However, external cervical root resorption, first detected at the 6-year follow-up, progressed by the ninth year. Despite the lack of clinical symptoms, radiographic findings suggested that the root resorption was a significant concern. This case underscores the potential for long-term success of autotransplanted teeth, even in complex scenarios involving fused teeth. However, it also highlights the importance of thorough, long-term monitoring to detect complications such as root resorption. The findings suggest that, while autotransplantation can offer favorable outcomes, careful management and periodic evaluations are essential to ensure the longevity of the transplanted tooth. © 2025 American Association of EndodontistsÖğe Dental age and tooth development in children with molar-incisor hypomineralization: A case-control study(Elsevier Ltd, 2022) Sezer, Berkant; Çarıkçıoğlu, Burak; Kargül, BetülObjective: The aim of the study was to determine the dental age for the evaluation of tooth development in children with molar-incisor hypomineralization (MIH) by using the Willems method, Cameriere-European formula, and London Atlas. Design: Panoramic radiographs of 308 children between the ages of 6–13 diagnosed with MIH and the same number of sex- and age-matched children without MIH were evaluated by two different examiners using the Willems method, Cameriere-European formula, and London Atlas. The mean difference between chronological age and dental age in both groups was calculated for each sex and age. The mean absolute error was used to determine the accuracies of the Willems method, Cameriere-European formula, and London Atlas. Results: There was a statistically significant difference found only in Willems method in dental age estimation between the groups with and without MIH (P = 0.001). In the evaluation performed with Cameriere-European formula and London Atlas, which are more accurate methods for dental age estimation in both groups, no statistically significant difference was found in dental age estimation between the two groups (P = 0.322, P = 0.290, respectively). There was a statistically significant intense linear correlation for three methods in both groups (P < 0.001). Conclusions: MIH, which is a developmental enamel defect, does not affect dental age and tooth development since there was no significant difference between groups with and without MIH according to the evaluations made with accurate dental age estimation methods.Öğe Evaluation of the differences in the localization of the lingula mandibulae according to pubertal development in children: A new anthropological and forensic approach(Elsevier Ltd, 2024) Eren, Hakan; Sezer, Berkant; Deniz, YeşimObjective: This study aims to investigate changes in lingula mandibulae localization before and after puberty and sex differences. Design: 288 panoramic radiographs evaluated retrospectively were divided into four groups according to pubertal development: under and over 10 years old for females and under and over 11 years old for males. Four anatomic sites were used as reference points: (a) the anterior border of the ramus; (b) the posterior border of the ramus; (c) the deepest point of mandibular notch; and (d) the angulus mandibulae. The ratio of the distances from the lingula mandibulae to points (a) and (b) and the ratio of the distances from the lingula mandibulae to points (c) and (d) were determined. Two-way ANOVA was performed to assess differences between subgroups based on sex and puberty, and a Bonferroni post-hoc test was performed for multiple comparisons. Results: Puberty and sex has a significant interaction effect on the vertical location of the lingula mandibulae. Postpubertal lingula mandibulae is positioned proportionally more anteriorly by prepubertal localization. In addition, the lingula mandibulae is situated more posteriorly in females compared to males. A significant interaction effect of puberty and sex was observed in relation to the vertical positioning of the lingula mandibulae. Conclusions: The spatial localization of the lingula mandibulae and its spatial displacement with age can be used both in estimating sex and the onset of puberty. Changes in the localization of lingula mandibulae according to pubertal development and sex can be used in forensic and anthropological contexts.Öğe Comparison of the Effects of WaveOne Gold, TruNatomy, and Conventional Hand Files on Remaining Dentin Volume in the Coronal Part of the Root and Preparation Efficiency in Mandibular Molars(Elsevier Inc., 2023) Eren, İrem; Sezer, BerkantIntroduction: The use of file systems that work with different principles in root canal treatment is becoming widespread. The aim of this study was to evaluate the remaining dentine volume in the coronal region of the root and preparation efficiency after the use of conventional hand files, WaveOne Gold; which works with reciprocating motion, and TruNatomy; which works with rotational motion in the root canal treatment of mandibular molar teeth. Methods: All canals of permanent mandibular molars (n = 36) were used. Root canals in each group (n = 12) were prepared with conventional hand files, WaveOne Gold, and TruNatomy. The three-dimensional images were evaluated for remaining dentine volume in the coronal two-millimeter region of the root and change in volume of the entire root canal space. Results: There was no statistically significant difference between the groups in terms of mean differences pre and postpreparation (P > .05). The mean differences after preparation were observed the most in the WaveOne Gold group and the least in the TruNatomy group in the coronal two-millimeter region of the root and entire canal volume, but the differences were not significant (P > .05, P > .05, respectively). Conclusions: Conventional hand files, WaveOne Gold working with reciprocating motion, and TruNatomy working with rotational motion, which are the file systems used in the study, are not superior to each other in terms of remaining dentin volume in the coronal two-millimeter region of the root and preparation efficiency in the entire root canal space in mandibular molars.Öğe Does the scientific literature provide sufficient information on incisors affected by molar incisor hypomineralisation?(Springer Science and Business Media Deutschland GmbH, 2023) Sezer, BerkantMolar incisor hypomineralisation (MIH), which was defined for the first time by Weerheijm et al. (2001) twenty-one years ago as a qualitative, hypomineralised enamel defect in which at least one permanent first molar is affected and the condition is frequently observed in permanent incisors, remains an important health problem.Öğe Assessment of the oral health status of children with chronic kidney disease(Springer Science and Business Media Deutschland GmbH, 2023) Sezer, Berkant; Kaya, Remziye; Kodaman Dokumacıgil, Nur; Sıddıkoğlu, Duygu; Güven, Serçin; Yıldız, Nurdan; Alpay, Harika; Kargül, BetülBackground There are various oral symptoms related to the disease and its management in individuals with chronic kidney disease (CKD). The aim of the study was to investigate the oral health status of children with different stages of CKD, kidney transplant recipients (KTR), and healthy children. Methods A total of seventy-one children diagnosed with CKD and fifty-two healthy children were included in the study. Each patient was examined for dental caries by the decayed-missing-filled-teeth (DMFT/dmft) index and the International Caries Detection and Assessment System (ICDAS-II), developmental defects of enamel (DDE) by the DDE index, and oral hygiene by the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indices. Results The median number of DMFT/dmft was 1.00 (interquartile range (IQR):1.00-4.00) in children with stage 1-3 CKD, 0.00 (IQR: 0.00-2.50) in stage 4-5 children, 0.00 (IQR: 1.00-3.00) in KTR, and 8.00 (IQR: 1.00-13.00) in healthy children. According to ICDAS-II categories, the percentage of children with severe caries was 53.8% in healthy children, while it was 44.4% in KTR, 25.9% in stage 1-3, and 11.4% in stage 4-5 children. While the percentage of children with DDE was 88.8% in KTR, 80% in stage 4-5, and 66.7% in stage 1-3 children, this rate was 44.2% in healthy children. The highest mean OHI-S score was observed in stage 4-5 children (2.10 +/- 1.08), followed by KTR (1.46 +/- 1.19), stage 1-3 (1.27 +/- 0.61), and healthy children (0.45 +/- 0.44), respectively. Conclusions Compared to healthy children, children with CKD had more debris accumulation, calculus formation, and more DDE but a lower severity of dental caries.Öğe Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study(Springer Science and Business Media Deutschland GmbH, 2023) Sezer, Berkant; Kodaman Dokumacıgil, Nur; Kaya, Remziye; Güven, Serçin; Türkkan, Özde Nisa; Çiçek, Neslihan; Alpay, Harika; Kargül, BetülObjectives: The aim of this study was to investigate the association between serum biomarkers and oral health parameters in children with chronic kidney disease (CKD). Materials and methods: Serum hemoglobin, blood urea nitrogen, serum creatinine, calcium, parathormone, magnesium, and phosphorus levels were measured in 62 children with CKD aged between 4 and 17 years. Intraoral examinations of the patients were performed by two different pediatric dentists. Dental caries was assessed using the decayed-missing-filled-teeth (DMFT/dmft) indexes, and oral hygiene was assessed using the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indexes. Spearman’s rho coefficient and generalized linear modeling were used to examine the association between serum biomarkers and oral health parameters. Results: The results of the study showed that there were negative and statistically significant correlations between serum hemoglobin and creatinine levels and dmft scores in pediatric patients with CKD (p = 0.021 and p = 0.019, respectively). Furthermore, blood urea nitrogen levels and DI and OHI-S scores (p = 0.047 and p = 0.050, respectively); serum creatinine levels and DI, CI, and OHI-S scores (p = 0.005, p = 0.047, p = 0.043, respectively); and parathormone levels and CI and OHI-S scores (p = 0.001 and p = 0.017, respectively) were found to be positively and statistically significantly related. Conclusions: There are associations between various serum biomarker levels and dental caries and oral hygiene parameters in pediatric patients with CKD. Clinical relevance: The impact of changes in serum biomarkers on oral and dental health is important for dentists’ and medical professionals' approaches to patients' oral and systemic health.Öğe Effects of radiotherapeutic X-ray irradiation on cervical enamel(Taylor and Francis Ltd., 2021) Deniz, Yeşim; Aktaş, Çağatay; Misilli, Tuğba; Çarıkçıoğlu, BurakPurpose Therapeutic radiation used for head and neck cancers mainly affects the cervical region of the tooth. To better understand the impact of therapeutic radiation on tooth, we aimed to examine the crystallinity, micro-morphology, and elemental composition of the cervical inner enamel located adjacent to the dento-enamel junction. Materials and methods Ninety-one specimens obtained from 16 impacted third mandibular molars were randomly divided into seven groups (0, 10, 20, 30, 40, 50, and 60 Gy irradiation groups). Energy-dispersive X-ray spectroscopy (EDX) and scanning electron microscopy (SEM) were performed after the irradiation by 6 MV photon energy. The X-ray diffraction (XRD) were conducted in every group before and after irradiation. Elemental compositions, and Ca/P, P/N, Ca/N atomic ratios were subjected to the Shapiro-Wilk normality test. All of the elements except Mg showed a normal distribution and were compared by the one-way ANOVA. The non-normally distributed Mg data and Ca/P, P/N, and Ca/N ratios were compared by the Kruskal-Wallis test. Results The results showed that widening in the interprismatic spaces were observed in the experimental groups subjected to 30 Gy and the following increased doses. In addition, there were no significant differences in C, O, Ca, P, N percentages between irradiated and non-irradiated groups (p > .05). An increase in atomic ratio of the Mg was detected after samples conducted by 60 Gy radiation dose (p < .05). The stoichiometric Ca/P, Ca/N, and P/N atomic ratios did not change by irradiation (p > .05). The XRD peaks of the inner enamel crystalline phase showed a slight decline in the 60 Gy radiation dose group. Conclusion Radiation effects begin to be seen after 30 Gy radiation dose groups. The widen interprismatic spaces seen obviously in 50 Gy and 60 Gy dose groups. Besides Mg ratio showed an increase in the 60 Gy dose group. But it should be thought that radiation caries is a multi-factorial disease that is in collaboration with various radiation-induced side effects.Öğe Accuracy of the radiographic methods of Willems, Cameriere and Blenkin-Evans on age estimation for Turkish children in the northwest Anatolia region(Taylor and Francis Ltd., 2021) Çarıkçıoğlu, Burak; Değirmenci, AlpinThe aim of this study is to compare the accuracy of the Willems Method (WM), Cameriere Method (CM) and Blenkin-Evans Method (BM) in the same study sample and determine which one is more suitable for Turkish population. This study included panoramic radiographs of 1024 individuals (619 boys and 585 girls) aged between 6.00 and 15.99 years. Dental age (DA) was calculated using WM, CM and BM for the total study sample, and separately, taking into account age groups and gender. Repeatability statistics evaluated with Cohen's Kappa test. The differences between chronological age (CA) and the DA were statistically tested using a paired sample t-test and the Wilcoxon signed-rank test. WM overestimated the CA by 0.23 years, while both CM and BM underestimated it by 0.51 and 0.05 years, respectively. In all samples, the DA-CA difference was significant in all methods with one exception BM in boys. Although WM and BM both seem satisfactory in age estimation for children at the northwest Anatolia region of Turkey, BM performs slightly better than CM and it has shown the most accurate results except for the 15 year age group.Öğe Accuracy of the London Atlas, Haavikko's Method and Cameriere's European Formula of dental age estimation in Turkish children(Elsevier B.V., 2022) Sezer, Berkant; Çarıkcıoğlu, BurakAge estimation is a mandatory procedure when the chronological age is unknown or uncertain. Dental development is the preferred characteristic for estimating a child's age. There are many methods for dental age estimation, but their reliability can differ between populations. This study compared the accuracy of three of these methods—the London Atlas (LA), Haavikko's method (HM), and Cameriere's European formula (CF)—in Turkish children living in northwestern Turkey. Panoramic radiographs of 980 children from northwestern Turkey aged between 6.00 and 14.99 years were examined for the whole study group and separately for different ages and sexes by all three methods. Statistical differences between chronological age and dental age were tested using the paired sample t-test and the Wilcoxon signed-rank test. The LA, HM, and CF accuracies were determined based on the mean absolute error. Spearman's rank correlation coefficient showed that the correlation between chronological age and dental age for both sexes was linear for all methods. The LA overestimated the chronological age by 0.09 years, while HM and CF underestimated it by 0.49 and 0.11 years, respectively. The difference between dental age and chronological age was significant in all samples, for all methods, except for the LA in boys. When boys, girls, and the total sample were evaluated, values with the lowest mean absolute error were obtained by HM and were statistically significant in all three groups. Therefore, HM is more accurate than the LA and CF for dental age estimation in Turkish children living in northwestern Turkey.Öğe The effect of coating material on the color stability of glass-ionomer-based restorative materials: an in-vitro study(Cumhuriyet University Faculty of Dentistry, 2021) Çarıkçıoğlu, BurakObjectives: The aim of this study was to determine the effect of coating on the color stability of different glass ionomer cements (GICs) after immersed in different children beverages. Materials and Methods: Four different GIC and a glass-ionomer coating material were used in this study. Disc shaped sixteen specimens of each GICs were done and divided into two groups, uncoated and coated (n=8). For color change, the specimens were immersed 7 day in the four solutions of cola, orange juice, chocolate milk and water. The color measurements were carried out before immersed solutions and at the end of the 1st and 7th days, using a spectrophotometer. The color change ΔE00 was calculated using the CIEDE2000 formula. Data were analyzed by Kruskall-Wallis and Wilcoxon test (p<0.05). Results: The ΔE00 values for all coated and uncoated GICs showed an increase in all solutions after 7 days of immersion. All the ΔE00 values obtained from all the specimens immersed in cola were higher than the acceptability threshold. There was no statistical difference in terms of ΔE00 values between the coated and uncoated specimens of the same GICs at same time periods. Conclusions: Coating of GICs exhibited relatively good color stability and protect from the discoloration. The staining effect of GICs should be carefully considered when selecting dental materials in pediatric dentistry.Öğe Motivations, attitudes for choosing dental profession and preferred dental specialties amongst Turkish dental students(John Wiley & Sons Ltd, 2022) Sezer, Berkant; Kolay, Duygu; Şen Yavuz, Betül; Güneyligil Kazaz, Tanyeli; Kargül, BetülAim: The aim of the study was to investigate the influential factors for choosing dentistry, their thoughts about the profession, their expectations for the future and their thoughts about the specialisation of dental students from all grades in the School of Dentistry, Marmara University. Materials and Methods: Socio-demographic information, influential factors the choice of profession, thoughts and expectations about dentistry, and thoughts about the specialisation were evaluated in the questionnaire that included different question types in four separate sections. Chi-square test was used to assess the relationship between categorical variables, and multiple linear regression was performed to examine the combined effects of variables that influence the always dream of becoming a dentist. Results: 462 of the 471 participants from all grades who agreed to participate in the study completed the questionnaire with a response rate of 98.1%. It was seen that the students' clinical experience made differences in almost half of their motivational sources for choosing dentistry and their views on future opinions and expectations (p <.05). In addition to clinical experience, gender also made a statistically significant differences in almost all answers in the students' opinions about specialisation (p <.05). Conclusion: From the results of the study, the majority of Turkish dental students were self-motivated compared to familial and environmental factors for choosing dentistry as a career. The career motivations of them seemed to be associated with the socioeconomic aspects of dentistry, whereas the perceptions regarding the future of dentistry seemed to be associated with the need for postgraduate education.Öğe Effects of high temperature on dental restorative materials for forensic purposes(Springer, 2021) Çarıkçıoglu, Burak; Misilli, Tuğba; Deniz, Yeşim; Aktaş, ÇağatayThis study aimed to observe the efects of high temperature on diferent restorative dental materials by detecting changes in their microstructural and elemental composition. Disk shaped samples (10 mm diameter, 2 mm depth) were prepared from 8 dental materials (compomer, glass carbomer, ormocer, giomer, zinc reinforced glass ionomer (GI), silver-alloy reinforced GI, zirconia reinforced GI, and conventional GI). Scanning electron microscopy/Energy dispersive X-ray spectroscopy (SEM/EDS) was used to characterize sample surface structures and elemental composition. The same samples were also analyzed using X-ray fuorescence (XRF) to determine the trace element content. Each sample was placed in a porcelain furnace and exposed to 900 °C for 30 min. Observations of macroscopic changes in samples after exposure high temperature were recorded. The microstructural changes in sample surfaces after incineration were detected by SEM. The elemental compositions obtained before and after the incineration were compared after repeating the XRF and EDS analyses. Dental materials demonstrated specifc macroscopic changes and microstructural deteriorations detected by SEM images after exposure to high temperature. While several changes occurred in the elemental content of materials in terms of amount, the original elemental composition was preserved. The ability to distinguish dental materials by elemental analyses has had an important impact on the identifcation process.
