Degradable and Non-Degradable Chondroitin Sulfate Particles with the Controlled Antibiotic Release for Bacterial Infections

Basit Öğe Kaydı
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:52:12Z
dc.date.available2025-01-27T20:52:12Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNon-degradable, slightly degradable, and completely degradable micro/nanoparticles derived from chondroitin sulfate (CS) were synthesized through crosslinking reactions at 50%, 40%, and 20% mole ratios, respectively. The CS particles with a 20% crosslinking ratio show total degradation within 48 h, whereas 50% CS particles were highly stable for up to 240 h with only 7.0 +/- 2.8% weight loss in physiological conditions (pH 7.4, 37 degrees C). Tobramycin and amikacin antibiotics were encapsulated into non-degradable CS particles with high loading at 250 g/mg for the treatment of corneal bacterial ulcers. The highest release capacity of 92 +/- 2% was obtained for CS-Amikacin particles with sustainable and long-term release profiles. The antibacterial effects of CS particles loaded with 2.5 mg of antibiotic continued to render a prolonged release time of 240 h with 24 +/- 2 mm inhibition zones against Pseudomonas aeruginosa. Furthermore, as a carrier, CS particles significantly improved the compatibility of the antibiotics even at high particle concentrations of 1000 g/mL with a minimum of 71 +/- 7% fibroblast cell viability. In summary, the sustainable delivery of antibiotics and long-term treatment of bacterial keratitis were shown to be afforded by the design of tunable degradation ability of CS particles with improved biocompatibility for the encapsulated drugs.
dc.description.sponsorshipOphthalmology Department at USF
dc.description.sponsorshipSome parts of this work was supported by the startup funds for Nurettin Sahiner from the Ophthalmology Department at USF.
dc.identifier.doi10.3390/pharmaceutics14081739
dc.identifier.issn1999-4923
dc.identifier.issue8
dc.identifier.pmid36015365
dc.identifier.scopus2-s2.0-85137408869
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics14081739
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25692
dc.identifier.volume14
dc.identifier.wosWOS:000845784400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPharmaceutics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectchondroitin sulfate
dc.subjectCS microgels
dc.subjectnanogels
dc.subjectcontrolled degradation
dc.subjectdrug delivery
dc.subjecttobramycin
dc.subjectamikacin
dc.subjectPseudomonas keratitis
dc.titleDegradable and Non-Degradable Chondroitin Sulfate Particles with the Controlled Antibiotic Release for Bacterial Infections
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Nurettin Sahiner_Makale.pdf
Boyut:
3.09 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyomühendislik Bölümü Koleksiyonu
Kimya Bölümü Koleksiyonu
Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezi Yayın Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu