Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial

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dc.authoridTunalı, Mustafa / 0000-0002-1251-3431en_US
dc.authorscopusidTunalı, Mustafa / 13407869100en_US
dc.authorwosidTunalı, Mustafa / AAA-1985-2020en_US
dc.contributor.authorSağlam, Ebru
dc.contributor.authorÖzsağır, Zeliha Betül
dc.contributor.authorÜnver, Tuğba
dc.contributor.authorAlınca, Suzan Bayer
dc.contributor.authorToprak, Ali
dc.contributor.authorTunalı, Mustafa
dc.date.accessioned2023-08-01T05:38:41Z
dc.date.available2023-08-01T05:38:41Z
dc.date.issued2021en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjective: Our study compared the effects of injectable platelet-rich fibrin (i-PRF) with those of corticosteroids in the treatment of erosive oral lichen planus (EOLP). Methodology: This split-mouth study included 24 individuals diagnosed histopathologically with bilateral EOLP. One bilateral lesion was injected with i-PRF, whereas the other was injected with methylprednisolone acetate in four sessions at 15-day intervals. Visual analog scale (VAS) for pain and satisfaction, oral health impact profile scale-14, and the lesion size were used. Results: The intragroup comparisons showed a significant decrease in VAS-pain and lesion size in both the i-PRF group (from 81.88 +/- 17.74 to 13.33 +/- 18.34, and from 4.79 +/- 0.41 to 1.88 +/- 1.08, respectively) and the corticosteroid group (from 80.21 +/- 17.35 to 23.33 +/- 26.81, and from 4.71 +/- 0.46 to 2.21 +/- 1.35, respectively) in the 6th month compared to baseline (p<0.001). Moreover, VAS-satisfaction increased significantly in both the i-PRF group (from 26.67 +/- 17.8 to 85.63 +/- 16.24) and the corticosteroid group (from 28.33 +/- 17.05 to 74.38 +/- 24.11) in the 6th month compared to baseline (p<0.001). However, no significant difference in any value occurred in the intergroup comparisons. Conclusion: In patients with EOLP, both methods decreased pain and lesion size similarly, and both increased satisfaction. Therefore, the use of i-PRF may be considered an option in cases refractory to topical corticosteroid therapy. Biochemical and histopathological studies are required to reveal the mechanism of i-PRF action in EOLP treatment.en_US
dc.identifier.citationSağlam, E., Özsağır, Z.B., Ünver, T., Alinca, S.B., Toprak, A., & Tunalı, M. (2021). Efficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial. Journal of Applied Oral Science, 29. https://doi.org/10.1590/1678-7757-2021-0180 ‌en_US
dc.identifier.doi10.1590/1678-7757-2021-0180
dc.identifier.issn1678-7757
dc.identifier.issn1678-7765
dc.identifier.pmid34614123
dc.identifier.scopus2-s2.0-85117087878
dc.identifier.urihttps://doi.org/10.1590/1678-7757-2021-0180
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4446
dc.identifier.volume29en_US
dc.identifier.wosWOS:000706102900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTunalı, Mustafa
dc.language.isoen
dc.publisherFaculdade De Odontologia De Bauruen_US
dc.relation.ispartofJournal of Applied Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectCorticosteroiden_US
dc.subjectOral lichen planusen_US
dc.subjectPatienreported outcome measuresen_US
dc.subjectPlatelet-rich fibrinen_US
dc.subjectWound healingen_US
dc.titleEfficacy of injectable platelet-rich fibrin in the erosive oral lichen planus: a split-mouth, randomized, controlled clinical trial
dc.typeArticle

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