Assessment of the relationship between neutrophil lymphocyte ratio and prognostic factors in non-metastatic colorectal cancer

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dc.authoridYilmaz, Latif/0000-0003-2528-9691
dc.authoridBaskonus, Ilyas/0000-0002-4191-3178
dc.authoridAYTEKIN, ALPER/0000-0003-2872-5276
dc.contributor.authorBorazan, Ersin
dc.contributor.authorBalik, Ahmet Abdulhalik
dc.contributor.authorBozdag, Zehra
dc.contributor.authorArik, Muhammed Kasim
dc.contributor.authorAytekin, Alper
dc.contributor.authorYilmaz, Latif
dc.contributor.authorElci, Muhsin
dc.date.accessioned2025-01-27T20:24:24Z
dc.date.available2025-01-27T20:24:24Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Neutrophil-lymphocyte ratio still has a limited clinical use due to many non-cancer factors affecting neutrophils or lymphocytes in the present time. We aimed to evaluate the association between preoperative neutrophillymphocyte ratio and poor prognostic factors after curative elective colorectal surgery. Material and Methods: This clinical retrospective study was initiated with 95 patients, who had a curative surgical resection between 2003 and 2013. The patients were divided into two groups based on the preoperative neutrophillymphocyte ratio cut-off value above and below 3. The groups were compared for tumor localization, diameter, and staging; the histopathological perineural invasion; lymphovascular invasion; and overall survival. Univariate and multivariate Cox regression analyses were used to determine the role of neutrophil-lymphocyte ratio after stratification by several clinicopathological factors. Results: The mean age of patients was 59.79 +/- 1.48 (range, 23-90) years, and median follow-up period was 20.77 +/- 14.85 months. There was no significant difference in perineural or lymphovascular invasion, tumor size, stage, age, sex, and tumor location between the groups [Group 1 ratio > 3 (n= 52) and Group 2 ratio = 3(n= 43)]. Hemoglobin (p= 0.035) and albumin levels (p= 0.004) were lower in the Group 1. When the stage increased, differences between the rectal cancer groups were found. Overall survival was significantly lower in the Group 1 (p= 0.013). Conclusions: The study showed that a high neutrophil-lymphocyte ratio had an adverse effect on overall survival in colorectal cancer patients who had a curative surgery. However, we could not establish any association between neutrophil-lymphocyte ratio and the factors such lymphovascular invasion, perineural invasion, tumor size expect hemoglobin and serum albumin levels.
dc.identifier.doi10.5152/turkjsurg.2017.3528
dc.identifier.endpage189
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.issue3
dc.identifier.pmid28944331
dc.identifier.scopus2-s2.0-85029540426
dc.identifier.scopusqualityQ3
dc.identifier.startpage185
dc.identifier.trdizinid243245
dc.identifier.urihttps://doi.org/10.5152/turkjsurg.2017.3528
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/243245
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22203
dc.identifier.volume33
dc.identifier.wosWOS:000410004200011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectColorectal cancer
dc.subjectlymphocyte
dc.subjectneutrophil
dc.subjectsurgery
dc.subjectoverall survival
dc.titleAssessment of the relationship between neutrophil lymphocyte ratio and prognostic factors in non-metastatic colorectal cancer
dc.typeArticle

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