Effects of a Single Application of Adcon Gel on Peritendinous Adhesion: An Experimental Study in Rabbits

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dc.contributor.authorOzden, Raif
dc.contributor.authorUruc, Vedat
dc.contributor.authorDuman, Ibrahim Gokhan
dc.contributor.authorDogramaci, Yunus
dc.contributor.authorKalaci, Aydiner
dc.contributor.authorKomurcu, Erkam
dc.contributor.authorOzsoy, Sule Yurdagul
dc.date.accessioned2025-01-27T20:11:46Z
dc.date.available2025-01-27T20:11:46Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPeritendinous adhesions are serious complications after surgical repair of tendons and can lead to poor functional outcome. In the present study, the tensile strength of repaired tendons was measured biomechanically in two groups using a rabbit Achilles tendon model, and the effects of Adcon gel on peritendinous adhesions and tendon healing were examined by means of histological and mechanical analyses. In the treatment group, the Achilles tendon was transected, followed by a primary repair using a modified Kessler technique, and Adcon gel was injected between the tendon and skin of the right leg. The same operation was done for the control group, and 1 mL of normal saline solution was applied locally in a similar fashion. The experimental protocols were approved by the local animal ethics committee. Microscopic evidence of the formation of adhesions and of inflammation was less in the treatment group than in the control group. There was no significant difference in the tensile load necessary to rupture the repaired tendons between the two groups. Adcon gel reduced the peritendinous adhesions histologically without impairing tendon healing, as determined with mechanical analyses. The use of Adcon gel may provide a simple means of preventing of postoperative peritendinous adhesions, thereby offering a beneficial effect on tendon repair.
dc.identifier.doi10.2485/jhtb.23.199
dc.identifier.endpage203
dc.identifier.issn1341-7649
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84898485902
dc.identifier.scopusqualityQ3
dc.identifier.startpage199
dc.identifier.urihttps://doi.org/10.2485/jhtb.23.199
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20716
dc.identifier.volume23
dc.identifier.wosWOS:000334561600008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJournal Hard Tissue Biology
dc.relation.ispartofJournal of Hard Tissue Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAdcon gel
dc.subjectTendon injury
dc.subjectPeritendinous adhesion
dc.titleEffects of a Single Application of Adcon Gel on Peritendinous Adhesion: An Experimental Study in Rabbits
dc.typeArticle

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