Acid Catalyzed One-pot Three-component Biginelli-type Synthesis of Some New Symmetrical Bis 3,4-dihydropyrimidin-2(1H)-ones/thiones

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dc.authoridGulten, Sirin/0000-0003-1735-0501
dc.contributor.authorGulten, Sirin
dc.contributor.authorArslan, Ezgi
dc.date.accessioned2025-01-27T20:20:35Z
dc.date.available2025-01-27T20:20:35Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBiologically important 21 new symmetrical bis 3,4-dihydropyrimidin-2(1H)-ones/thiones were synthesized by reacting 4,4 '-diaminodiphenyl ether/4,4 '-ethylenedianiline with tert-butyl acetoacetate to produce diphenyl ether-bridged bis beta-keto amide/diphenyl ethane-bridged bis beta-keto amide then treated with urea or thiourea and an appropriate aldehyde with either a catalytic amount of p-TSA center dot H2O or conc. HCl in ethanol afforded the title compounds.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Department [FYL-2014-178]
dc.description.sponsorshipThis study was financially supported by Canakkale Onsekiz Mart University Scientific Research Projects Coordination Department (project no: FYL-2014-178). The authors thank to NMR Analysis Laboratory of Hacettepe University and Gazi University for recording NMR spectra and Central Laboratory of Pharmacy, Ankara University, for the measurement of the mass spectra and elemental analysis.
dc.identifier.doi10.1002/jhet.3367
dc.identifier.endpage2945
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85056197815
dc.identifier.scopusqualityQ2
dc.identifier.startpage2936
dc.identifier.urihttps://doi.org/10.1002/jhet.3367
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21757
dc.identifier.volume55
dc.identifier.wosWOS:000453457300032
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectChloride
dc.subjectDihydropyrimidinones
dc.subjectDerivatives
dc.subjectBlockers
dc.subjectBromide
dc.subjectDiethyl
dc.titleAcid Catalyzed One-pot Three-component Biginelli-type Synthesis of Some New Symmetrical Bis 3,4-dihydropyrimidin-2(1H)-ones/thiones
dc.typeArticle

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