Novel hydrogel particles and their IPN films as drug delivery systems with antibacterial properties

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dc.authoridSılan, Coşkun / 0000-0002-8352-6571
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridAlper Akçalı / 0000-0003-0325-886X
dc.authoridBütün Şengel, Sultan / 0000-0001-7036-2224
dc.authoridTatman Otkun, Müşerref / 0000-0001-8977-1140
dc.authoridÖzgür, Özay / 0000-0001-6589-9844
dc.contributor.authorSılan, Coşkun
dc.contributor.authorAlper Akçalı
dc.contributor.authorTatman Otkun, Müşerref
dc.contributor.authorÖzbey, Nilgün
dc.contributor.authorBütün, Sultan
dc.contributor.authorÖzay, Özgür
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:14:15Z
dc.date.available2025-01-27T20:14:15Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPoly(acrylonitrile) (p(AN))-based materials such poly(acrylonitrile-co-(3-acrylamidopropyl)-trimethylammonium chloride (p(AN-co-APTMACl)), poly(acrylonitrile-co-4-viniyl pyridine) (p(AN-co-4-VP)) and poly(acrylonitrile-co-N-isopropylacrylamide) (p(AN-co-NIPAM)) core-shell nanoparticles were prepared. The core materials, AN, in p(AN-co-4-VP) nanoparticles, were amidoximated and the shell materials, 4-VP, were quaternized to generate p(AN-co-4-VP)(+) and p(AN-co-4-VP)(++), single and double positively charged core-shell nanoparticles, respectively. Furthermore, interpenetrating microgels-hydrogel (IPN) polymeric networks were prepared by mixing double quaternized p(AN-co-4-VP)(++) core-shell particles with acrylamide (AAm) and 2-hydroxyethylmethacrylate (HEMA) before polymerization. A model drug, fluorescein sodium salt (FSS) was used in absorption/release studies from these IPNs. Moreover, the prepared and chemically modified particles were tested against Staphylococcus aureus ATCC6538. Pseduomonas aeruginosa ATCC9027. Bacillus subtilis ATCC6633, and Escherichia coli ATCC8739, and found that some of these particles had antibacterial properties against tested bacteria. (C) 2011 Elsevier B.V. All rights reserved.
dc.description.sponsorshipTurkish Academy of Science
dc.description.sponsorshipN. Sahiner is grateful to the Turkish Academy of Science for financial support under the 2008 TUBA-GEBIP program.
dc.identifier.doi10.1016/j.colsurfb.2011.09.024
dc.identifier.endpage253
dc.identifier.issn0927-7765
dc.identifier.pmid21978555
dc.identifier.scopus2-s2.0-80054999142
dc.identifier.scopusqualityQ1
dc.identifier.startpage248
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2011.09.024
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21020
dc.identifier.volume89
dc.identifier.wosWOS:000297495000036
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPolymeric particles
dc.subjectMicrogel
dc.subjectNanogel
dc.subjectAntibacterial materials
dc.subjectDrug delivery systems
dc.titleNovel hydrogel particles and their IPN films as drug delivery systems with antibacterial properties
dc.typeArticle

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