A new nonsurgical experimental model for Asherman syndrome created in rats

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dc.contributor.authorBüyük, Başak
dc.date.accessioned2025-01-27T19:26:45Z
dc.date.available2025-01-27T19:26:45Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Asherman Syndrome (AS) is a partial or complete obstruction of the uterine cavity with adhesions as a result of trauma. In pre-clinical studies, to be able to show the effectiveness of new treatment methods, first of all, the AS model needs to be created in the animals. The aim of this study is to develop a new and effective nonsurgical method for using in AS and intrauterine adhesions modeling, and through this way, to propose a more effective method for researchers in terms of safety and feasibility. Methods: Twelve female Wistar Albino rats were divided into two groups. It was reached to the left uterine horn transvaginally by using pre-prepared pink color (20 gauge) cannula. While 0.2 ml normal saline was applied to the animals in Group I (control group), 0.2 ml (Trichloroacetic acid) TCA was applied to the animals in Group II (experiment group).The right uterine horns of the animals were left without treatment. After three menstrual cycles, the animals were sacrificed and Hematoxylin-Eosin and Masson’s Trichrom stainings were performed and evaluated histopathologically. Inflammation was evaluated in Hematoxylin-Eosin staining and fibrosis was evaluated in Masson’s Trichrom staining. Results: Whereas the uterine sections of the Group I have normal histologic appearance, inflammation and fibrosis were found in the left uterine sections of the Group 2 by histopathological evaluation. Results were statistically significant (p=0.002). Conclusion: The proposed nonsurgical AS modeling method created disease, and this was also revealed by histopathological examinations. Through this way, a new AS model is suggested without surgery, in which the disease is correctly created.
dc.identifier.doi10.25000/acem.434883
dc.identifier.endpage151
dc.identifier.issn2564-6567
dc.identifier.issue3
dc.identifier.startpage148
dc.identifier.trdizinid318902
dc.identifier.urihttps://doi.org/10.25000/acem.434883
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/318902
dc.identifier.urihttps://hdl.handle.net/20.500.12428/15615
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofArchives of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectCerrahi
dc.titleA new nonsurgical experimental model for Asherman syndrome created in rats
dc.typeArticle

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