The influence of ?-adducin gene polymorpism on response of blood pressure to exercise in patients with hypertension

Basit Öğe Kaydı
dc.authoridTURK, UGUR ONSEL/0000-0001-6348-6616
dc.contributor.authorAlioglu, Emin
dc.contributor.authorErcan, Ertugrul
dc.contributor.authorTengiz, Istemihan
dc.contributor.authorTurk, Ugur Onsel
dc.contributor.authorErgun, Metin
dc.contributor.authorAkgoz, Semra
dc.contributor.authorIslegen, Cetin
dc.date.accessioned2025-01-27T20:44:15Z
dc.date.available2025-01-27T20:44:15Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Clinical studies have indicated that an excessive response of blood pressure (BP) to exercise predicts risk of cardiovascular mortality. Although the mechanism responsible for the excessive BP response to exercise has not been revealed, there are some plausible mechanisms linking with underlying structural abnormalities in the cardiovascular system. Carriers of the Trp460 allele of the alpha-adducin Gly460Trp polymorphism have an increased risk of hypertension. The aim of the present study was to examine the influence of alpha-adducin gene polymorphism on response of BP to exercise in patients with hypertension. Methods: The cross-sectional observational study consisted of 49 hypertensive patients (29 women and 20 men; mean age, 53.1 +/- 8.8 years). All participants underwent a multistage exercise treadmill test according to the Bruce protocol. Arterial BPs were compared at rest, peak exercise and end of the recovery phase. Patients were classified according to their alpha-adducin gene polymorphisms; Gly460Gly homozygotes - Group 1 (n=28) and Trp460Trp homozygotes and Gly460Trp heterozygotes - Group 2 (n=21). Statistical analysis was performed using Chi-square, unpaired t, Mann-Whitney U and ANCOVA tests. Results: Mean exercise duration and mean exercise capacity in metabolic equivalents were not different between Group 1 and 2. The major finding of the study was that systolic BP responses at peak exercise and recovery period (3. min) were significantly higher (p=0.036) in hypertensive patients carrying at least one Trp460 allele of the alpha-adducin gene. Conclusion: Our results suggest that genetic variants that alter renal function and/or vasoreactivity are logical candidates to explain some of the individual variability in the BP response to exercise. (Anadolu Kardiyol Derg 2010; 10: 400-4)
dc.identifier.doi10.5152/akd.2010.136
dc.identifier.endpage404
dc.identifier.issn1302-8723
dc.identifier.issue5
dc.identifier.pmid20929695
dc.identifier.scopus2-s2.0-78049349523
dc.identifier.scopusqualityN/A
dc.identifier.startpage400
dc.identifier.urihttps://doi.org/10.5152/akd.2010.136
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24521
dc.identifier.volume10
dc.identifier.wosWOS:000283682400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves Yayincilik
dc.relation.ispartofAnadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectGene polymorphism
dc.subjectalpha-adducin
dc.subjectessential hypertension
dc.subjectexercise
dc.titleThe influence of ?-adducin gene polymorpism on response of blood pressure to exercise in patients with hypertension
dc.title.alternativeHipertansiyonu olan hastalarda egzersize kan basıncı cevabı üzerine ?-addusin gen polimorfizminin etkisi
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu